doi: 10.1016/0014-5793(88)80066-8.
Superoxide production from nonenzymatically glycated protein
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- PMID: 2842191
- DOI: 10.1016/0014-5793(88)80066-8
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Superoxide production from nonenzymatically glycated protein
FEBS Lett.
.
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Abstract
Nonenzymatically glycated human serum albumin and glycated poly-lysine(Lys) in vitro brought about the reduction of nitroblue tetrazolium and ferricytochrome c at pH 9.06 and pH 7.8, respectively. This reduction was inhibited partially by superoxide dismutase (SOD). Glycated poly-Lys caused the oxidation of NADH in the presence of LDH at pH 7.0 which was completely inhibited by SOD. Glycated material was found to function both as a reductant and an oxidant. The reactivity of glycated material is discussed and a possible mechanism by which superoxide is produced is proposed. Results may give a clue to diabetic complications.
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