Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Jul;66(1):280-282.
doi: 10.1002/hep.29220. Epub 2017 Jun 7.

Regulome networks and mutational landscape in liver cancer: An informative path to precision medicine

Song Yi  1 , Nidhi Sahni  1   2
Affiliations
Comment

Regulome networks and mutational landscape in liver cancer: An informative path to precision medicine

Song Yi et al. Hepatology. 2017 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Potential conflict of interest

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.. Complex genetic heterogeneity and regulome network rewiring in liver cancer.
Model of pleiotropic clinical outcomes resulting from distinct regulome network perturbation patterns induced by distinct cancer mutations. STVs, structural variations. Rectangles, coding genes. Stars, mutations. Coloured circles, different macromolecules. Edges, interactions between molecules.
See this image and copyright information in PMC

Comment on

  • Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.
    Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano K, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T, Nakagawa H. Fujimoto A, et al. Nat Genet. 2016 May;48(5):500-9. doi: 10.1038/ng.3547. Epub 2016 Apr 11. Nat Genet. 2016. PMID: 27064257

References

    1. Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet 2016;48:500–509. - PubMed
    1. Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, Ishikawa S, Tsutsumi S, et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat Genet 2011;43:464–469. - PubMed
    1. Khurana E, Fu Y, Chakravarty D, Demichelis F, Rubin MA, Gerstein M. Role of non-coding sequence variants in cancer. Nat Rev Genet 2016;17:93–108. - PubMed
    1. Sahni N, Yi S, Zhong Q, Jailkhani N, Charloteaux B, Cusick ME, Vidal M. Edgotype: a fundamental link between genotype and phenotype. Curr Opin Genet Dev 2013;23:649–657. - PMC - PubMed
    1. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, et al. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 2015;161:647–660. - PMC - PubMed