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Comment
. 2017 Apr 18;46(4):521-522.
doi: 10.1016/j.immuni.2017.04.002.

The Birds, the Bees, and Innate Immunity

Glen N Barber  1
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The Birds, the Bees, and Innate Immunity

Glen N Barber. Immunity. .
Free article

Abstract

The cytoplasm is usually a DNA-free zone, but during fertilization, sperm DNA enters oocyte cytoplasm and could potentially trigger a response. Abe et al. (2017) identify NLRP14 as a germ-cell-specific negative regulator of DNA sensing that may be of particular importance during fertilization.

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