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Comment
. 2017 Apr 18;46(4):527-529.
doi: 10.1016/j.immuni.2017.04.001.

Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?

Hugo Mouquet  1
Affiliations
Free article
Comment

Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?

Hugo Mouquet. Immunity. .
Free article

Abstract

The persistence of viruses "hidden" in a reservoir of latently infected CD4+ T cells under antiretroviral therapy is the major obstacle to an HIV-1 cure. Recently published in Nature, two seminal studies from Descours et al. (2017) and Nishimura et al. (2017) bring hope for tracking and possibly eradicating the HIV-1 reservoir.

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  • Early antibody therapy can induce long-lasting immunity to SHIV.
    Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foulds KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA. Nishimura Y, et al. Nature. 2017 Mar 23;543(7646):559-563. doi: 10.1038/nature21435. Epub 2017 Mar 13. Nature. 2017. PMID: 28289286 Free PMC article.
  • CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses.
    Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C, Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M. Descours B, et al. Nature. 2017 Mar 23;543(7646):564-567. doi: 10.1038/nature21710. Epub 2017 Mar 15. Nature. 2017. PMID: 28297712