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Comment
. 2017 Apr 18;46(4):529-531.
doi: 10.1016/j.immuni.2017.04.003.

Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

Janna Krueger  1 , Christopher E Rudd  2
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Free article
Comment

Two Strings in One Bow: PD-1 Negatively Regulates via Co-receptor CD28 on T Cells

Janna Krueger et al. Immunity. .
Free article

Abstract

The identity of PD-1 dependency on other receptors and signaling has been unclear. In a recent issue of Science, Hui et al. (2017) and Kamphorst et al. (2017) now show that CD28 expression is a target of PD-1-associated phosphatases and is needed for T cell expansion in anti-PD-1 immunotherapy.

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