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Comment
. 2017 Apr 19;9(386):eaan2781.
doi: 10.1126/scitranslmed.aan2781.

Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check

Brian A Jonas  1
Affiliations
Comment

Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check

Brian A Jonas. Sci Transl Med. .

Abstract

An oncolytic vaccinia virus expressing CXCL11 combined with PD-L1 blockade significantly reduces tumor burden and improves survival in murine cancer models.

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References

    1. Liu Z, Ravindranathan R, Kalinski P, Guo ZS, Bartlett DL. Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy. Nat Commun. 2017;8:14754. - PMC - PubMed