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Review
. 2017 Apr 5:5:31.
doi: 10.3389/fcell.2017.00031. eCollection 2017.

PTK7 Faces the Wnt in Development and Disease

Hanna Berger  1 , Andreas Wodarz  2   3 , Annette Borchers  1   4
Affiliations
Review

PTK7 Faces the Wnt in Development and Disease

Hanna Berger et al. Front Cell Dev Biol. .

Abstract

PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor regulating various processes in embryonic development and tissue homeostasis. On a cellular level PTK7 affects the establishment of cell polarity, the regulation of cell movement and migration as well as cell invasion. The PTK7 receptor has been shown to interact with ligands, co-receptors, and intracellular transducers of Wnt signaling pathways, pointing to a function in the fine-tuning of the Wnt signaling network. Here we will review recent findings implicating PTK7 at the crossroads of Wnt signaling pathways in development and disease.

Keywords: PTK7; Wnt signaling; cancer; neural tube defect; planar cell polarity; scoliosis.

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