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. 2017 Sep;27(5):1655-1660.
doi: 10.1007/s10895-017-2102-6. Epub 2017 Apr 19.

A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals

Rui Guo  1 , Qiuan Wang  2 , Weiying Lin  3   4
Affiliations

A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu2+ in Living Cells and Animals

Rui Guo et al. J Fluoresc. 2017 Sep.

Abstract

We have rationally constructed a novel ratiometric and near-infrared Cu2+ fluorescent probe based on a tricarbocyanine chromophore. The new probe NIR-Cu showed a ratiometric fluorescent response to Cu2+ with a large emission wavelength shift (up to 142 nm) in the far-red to near-infrared region. The probe also displayed a large variation in the fluorescence ratio (I636/I778) to Cu2+ species with high sensitivity and selectivity. Additionally, the developed probe NIR-Cu was suitable for fluorescence imaging of Cu2+ in living cells and mice.

Keywords: Cu2+; Fluorescent probe; NIR; Ratiometric.

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