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Review
. 2017 Apr;6(2):131-138.
doi: 10.2217/cns-2016-0039.

Review of stereotactic radiosurgery for intradural spine tumors

Taylor E Purvis  1 , C Rory Goodwin  1 , Daniel Lubelski  1 , Ilya Laufer  2 , Daniel M Sciubba  1
Affiliations
Review

Review of stereotactic radiosurgery for intradural spine tumors

Taylor E Purvis et al. CNS Oncol. 2017 Apr.

Abstract

Stereotactic radiosurgery (SRS) has become an increasingly popular treatment modality for spinal tumors due to its noninvasive and targeted approach. Whether SRS has the promise of relieving pretreatment symptoms and providing local tumor control for patients with intradural spine tumors is still debated. This review explores the current literature on SRS treatment for both metastatic and benign intradural tumors, with a focus on differential use for intramedullary and intradural extramedullary neoplasms. Although mortality rates from underlying malignant disease remain high, SRS may benefit patients with spinal metastatic lesions. Benign tumors have shown a promising response to SRS therapy with low rates of complications. Larger studies are necessary to determine the indications and outcome profile of SRS for intradural spinal neoplasms.

Keywords: intradural tumors; spine metastases; stereotactic radiosurgery.

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Conflict of interest statement

Financial & competing interests disclosure

CR Goodwin is a UNCF Merck Postdoctoral Fellow and has received an award from the Burroughs Wellcome Fund and the Johns Hopkins Neurosurgery Pain Research Institute. I Laufer has consulting relationships with Globus, DePuy/Synthes and SpineWave. DM Sciubba has consulting relationships with Medtronic, Globus, DePuy and Orthofix. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

References

    1. Traul DE, Shaffrey ME, Schiff D. Part I: spinal-cord neoplasms-intradural neoplasms. Lancet Oncol. 2007;8(1):35–45. - PubMed
    1. Hsu W, Nguyen T, Kleinberg L, et al. Stereotactic radiosurgery for spine tumors: review of current literature. Stereotact. Funct. Neurosurg. 2010;88(5):315–321. - PubMed
    1. Sohn S, Chung CK. The role of stereotactic radiosurgery in metastasis to the spine. J. Korean Neurosurg. Soc. 2012;51(1):1–7. - PMC - PubMed
    1. Gerszten PC, Mendel E, Yamada Y. Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes? Spine (Phila PA 1976) 2009;34(22 Suppl.):S78–S92. - PubMed
    1. Linskey ME, Andrews DW, Asher AL, et al. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 2010;96(1):45–68. - PMC - PubMed

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