Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor
- PMID: 2842697
- DOI: 10.1007/BF00182730
Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor
Abstract
KCl-, NMDA-, and glycine-evoked release of [3H]acetylcholine was studied in superfused rat striatal slices. KCl-evoked release of [3H]acetylcholine was inhibited by 1.2 mM MgCl2 and 100 microM lidocaine. Similarly, NMDA-evoked release was inhibited by MgCl2 and lidocaine as well as 10 microM CGS 19755, a competitive antagonist at NMDA receptors, and 10 nM MK-801, a noncompetitive antagonist of NMDA-induced responses. Glycine-evoked release was calcium-dependent and was inhibited by 0.1 microM strychnine whereas KCl- and NMDA-evoked release were resistant to strychnine. In addition, lidocaine inhibited the glycine-induced response. Cross-tachyphylaxis was not observed between NMDA- and glycine-evoked release. These results indicate that the strychnine-sensitive, glycine-evoked release of [3H]acetylcholine is independent of the NMDA receptor.
Similar articles
-
Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices.Neurosci Lett. 1989 Jan 30;96(3):323-8. doi: 10.1016/0304-3940(89)90399-6. Neurosci Lett. 1989. PMID: 2541381
-
Inhibitory and potentiating influences of glycine on N-methyl-D-aspartate-evoked dopamine release from cultured rat mesencephalic cells.Mol Pharmacol. 1991 Feb;39(2):205-10. Mol Pharmacol. 1991. PMID: 1825345
-
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.J Neurochem. 1994 May;62(5):1835-9. doi: 10.1046/j.1471-4159.1994.62051835.x. J Neurochem. 1994. PMID: 7908945
-
Trans-2-carboxy-3-pyrrolidineacetic acid (CPAA), a novel agonist at NMDA-type receptors.Neurosci Lett. 1988 Oct 17;92(3):298-302. doi: 10.1016/0304-3940(88)90606-4. Neurosci Lett. 1988. PMID: 2849073
-
Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons.J Neurochem. 1988 Dec;51(6):1765-70. doi: 10.1111/j.1471-4159.1988.tb01157.x. J Neurochem. 1988. PMID: 2846784
Cited by
-
Dissociating scopolamine-induced disrupted and persistent latent inhibition: stage-dependent effects of glycine and physostigmine.Psychopharmacology (Berl). 2010 Apr;209(2):175-84. doi: 10.1007/s00213-010-1785-z. Epub 2010 Feb 24. Psychopharmacology (Berl). 2010. PMID: 20179909
-
Glycine stimulates striatal dopamine release in conscious rats.Br J Pharmacol. 1993 Sep;110(1):50-3. doi: 10.1111/j.1476-5381.1993.tb13770.x. Br J Pharmacol. 1993. PMID: 8220914 Free PMC article.
-
Evidence for strychnine-sensitive glycine receptors in human amygdala.Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):181-7. doi: 10.1007/s00210-003-0786-4. Epub 2003 Aug 16. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12923611
-
Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: role of glutamic acid.Neurochem Res. 1992 Mar;17(3):265-71. doi: 10.1007/BF00966669. Neurochem Res. 1992. PMID: 1352387
-
Long-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine.Cell Mol Neurobiol. 2005 Jun;25(3-4):767-76. doi: 10.1007/s10571-005-3974-6. Cell Mol Neurobiol. 2005. PMID: 16075390 Free PMC article.