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. 1988 May;337(5):552-5.
doi: 10.1007/BF00182730.

Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor

C A Taylor  1 , C Tsai, J Lehmann
Affiliations

Glycine-evoked release of [3H]acetylcholine from rat striatal slices is independent of the NMDA receptor

C A Taylor et al. Naunyn Schmiedebergs Arch Pharmacol. 1988 May.

Abstract

KCl-, NMDA-, and glycine-evoked release of [3H]acetylcholine was studied in superfused rat striatal slices. KCl-evoked release of [3H]acetylcholine was inhibited by 1.2 mM MgCl2 and 100 microM lidocaine. Similarly, NMDA-evoked release was inhibited by MgCl2 and lidocaine as well as 10 microM CGS 19755, a competitive antagonist at NMDA receptors, and 10 nM MK-801, a noncompetitive antagonist of NMDA-induced responses. Glycine-evoked release was calcium-dependent and was inhibited by 0.1 microM strychnine whereas KCl- and NMDA-evoked release were resistant to strychnine. In addition, lidocaine inhibited the glycine-induced response. Cross-tachyphylaxis was not observed between NMDA- and glycine-evoked release. These results indicate that the strychnine-sensitive, glycine-evoked release of [3H]acetylcholine is independent of the NMDA receptor.

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