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Randomized Controlled Trial
. 2017 May 23;116(11):1389-1393.
doi: 10.1038/bjc.2017.112. Epub 2017 Apr 20.

Long-term improvement of breast cancer survivors' quality of life by a 2-week group physical and educational intervention: 5-year update of the 'PACThe' trial

Fabrice Kwiatkowski  1 , Marie-Ange Mouret-Reynier  2 , Martine Duclos  3 , François Bridon  4 , Thierry Hanh  5 , Isabelle Van Praagh-Doreau  2 , Armelle Travade  6 , Marie-Paule Vasson  7 , Sylvie Jouvency  7 , Christian Roques  8 , Yves-Jean Bignon  9
Affiliations
Randomized Controlled Trial

Long-term improvement of breast cancer survivors' quality of life by a 2-week group physical and educational intervention: 5-year update of the 'PACThe' trial

Fabrice Kwiatkowski et al. Br J Cancer. .

Abstract

Background: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking.

Methods: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients post-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements.

Results: QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (-0.01; 0.56), 0.28 (-0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80). Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist -2.4% (-3.6; -1.1) (P=0.000014) and -1.3% (-2.5; -0.1) (P=0.0072).

Conclusions: A 2-week intervention in hydrothermal centres performed shortly after chemotherapy can durably improve breast cancer patients' QoL and reduce weight.

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Conflict of interest statement

RC is involved in the AFRETH council. His role was to supervise the global study methodology/design and check for the trial quality. He did not interfere with the management of the trial, nor with statistical calculations and manuscript preparation.

Figures

Figure 1
Figure 1
Inclusion flowchart and data count at each time-point. Qol, quality of life; diet, nutritional+anthropometric data.
Figure 2
Figure 2
Evolution of SF36 quality of life scores (ranking from 0=worst to 100=best) according to allocation group (A) QoL global score (B) Mental and Physical sub-scores (error bars correspond to 95% confidence interval).
Figure 3
Figure 3
Weight and waist-girth variations by allocation group over 3 years (=% differences between measures at inclusion and those at each time points) Error bars correspond to 95% confidence interval).
See this image and copyright information in PMC

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