Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 May 23;8(21):34507-34515.
doi: 10.18632/oncotarget.15671.

Human papillomavirus infection as a prognostic marker for lung adenocarcinoma: a systematic review and meta-analysis

Lanwei Guo  1 , Shuzheng Liu  1 , Shaokai Zhang  1 , Qiong Chen  1 , Meng Zhang  1 , Peiliang Quan  1 , Xibin Sun  1
Affiliations
Meta-Analysis

Human papillomavirus infection as a prognostic marker for lung adenocarcinoma: a systematic review and meta-analysis

Lanwei Guo et al. Oncotarget. .

Abstract

Although a number of studies have investigated the association between human papillomavirus (HPV) and lung cancer prognosis, the results remain inconsistent. We therefore conducted a meta-analysis of epidemiologic studies to address this issue. Searches of the MEDLINE and EMBASE electronic databases from their inception until June 30, 2016 yielded nine studies involving a total of 1,205 lung cancer cases that were used to conduct the meta-analysis. Study-specific risk estimates were pooled using a random-effects model. The pooled hazard ratio (HR) comparing HPV-positive to HPV-negative cancers 1.00 (95% confidence interval (CI): 0.78-1.28) was not significantly correlated with overall survival. However, lung adenocarcinoma patients with HPV infections exhibited a survival benefit compared to those without HPV infection (HR=0.69, 95% CI: 0.50-0.96). This meta-analysis suggests HPV infection is a prognostic marker in lung adenocarcinoma. To further elucidate the epidemiology and pathogenesis of HPV infections in lung cancer, future large prospective studies are encouraged to stratify survival analysis based on the pathological type and clinical stage of the cancer.

Keywords: HPV; lung cancer; meta-analysis; prognosis.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of systematic literature search
Figure 2
Figure 2. Forest plot comparing HPV-positive to HPV-negative lung cancer patients and overall survival
Figure 3
Figure 3. Influence analyses for omitting individual study on the summary HR for overall survival
Figure 4
Figure 4. Funnel plots for publication bias of overall survival
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ervik M, Lam M, Ferlay J, Mery L, Soerjomataram I, Bray F. Cancer Today. Lyon, France: International Agency for Research on Cancer; 2016. Cancer Today. Available from: http://gco.iarc.fr/ today, accessed [09/07/2016]
    1. Spyratos D, Zarogoulidis P, Porpodis K, Tsakiridis K, Machairiotis N, Katsikogiannis N, Kougioumtzi I, Dryllis G, Kallianos A, Rapti A. Occupational exposure and lung cancer. Journal of thoracic disease. 2013;5:S440–445. - PMC - PubMed
    1. Hajdu SI, Ali SZ. Discovery of human papillomavirus in carcinoma of the lung. Annals of clinical and laboratory science. 2008;38:3–5. - PubMed
    1. de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N, Bosch FX. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. The Lancet Infectious diseases. 2007;7:453–459. - PubMed
    1. Ndiaye C, Mena M, Alemany L, Arbyn M, Castellsague X, Laporte L, Bosch FX, de Sanjose S, Trottier H. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. The Lancet Oncology. 2014;15:1319–1331. - PubMed