Mirtazapine-induced steatosis
- PMID: 28427497
- DOI: 10.5414/CP202983
Mirtazapine-induced steatosis
Abstract
Mirtazapine is a commonly used drug indicated for the treatment of severe depression. It works as a presynaptic α2-adrenoreceptor antagonist that increases central noradrenergic and serotonergic neurotransmission, and it is metabolized by the p450 cytochrome oxidase system. There is evidence within the literature to suggest a link between antidepressants and increased liver enzymes, although case reports demonstrating a link between mirtazapine specifically and steatosis are sparse. Here, we present a case of mirtazapine-induced steatosis in a 48-year-old office worker. She presented with painless jaundice of 2 days duration and generalized lethargy and peripheral edema present for 3 weeks beforehand. Extensive investigations were undertaken to identify the cause of her jaundice but no biochemical, blood-borne, or anatomical cause could be found. Mirtazapine was subsequently stopped, and her liver function, both clinically and biochemically, improved rapidly. She made a full recovery after discontinuation of her mirtazapine. .
Similar articles
-
Mirtazapine-induced hepatotoxicity.J Clin Gastroenterol. 2002 Sep;35(3):270-1. doi: 10.1097/00004836-200209000-00014. J Clin Gastroenterol. 2002. PMID: 12192206
-
Mirtazapine-induced hepatocellular-type liver injury.Ann Pharmacother. 2011 Jun;45(6):825-6. doi: 10.1345/aph.1Q078. Epub 2011 Jun 10. Ann Pharmacother. 2011. PMID: 21666084 No abstract available.
-
The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission.Int Clin Psychopharmacol. 1995 Dec;10 Suppl 4:19-23. doi: 10.1097/00004850-199512004-00004. Int Clin Psychopharmacol. 1995. PMID: 8930006 Review.
-
A risk-benefit assessment of mirtazapine in the treatment of depression.Drug Saf. 1997 Oct;17(4):251-64. doi: 10.2165/00002018-199717040-00005. Drug Saf. 1997. PMID: 9352961 Review.
-
Noradrenergic modulation of central serotonergic neurotransmission: acute and long-term actions of mirtazapine.Int Clin Psychopharmacol. 1995 Dec;10 Suppl 4:11-7. doi: 10.1097/00004850-199512004-00003. Int Clin Psychopharmacol. 1995. PMID: 8930005 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical