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Comment
. 2017 Apr 20;129(16):2214-2215.
doi: 10.1182/blood-2017-03-771501.

Complement and clot

Vahid Afshar-Kharghan  1
Affiliations
Comment

Complement and clot

Vahid Afshar-Kharghan. Blood. .

Abstract

In this issue of Blood, Subramaniam et al showed that complement proteins affect platelet activation and tissue factor (TF) procoagulant activity (PCA) in an inferior vena cava (IVC) ligation model of venous thrombosis in mice.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Complement proteins participate in venous thrombosis after ligation of the IVC. C3 has a role in activation of platelets. C5 has a role in activation of TF on leukocytes. The effect of C5 on TF activation depends on the assembly of C5b-7, expression of phosphatidylserine (PS), and activity of protein disulfide isomerase (PDI) on the cell membrane. Illustration by The University of Texas MD Anderson Cancer Center.
See this image and copyright information in PMC

Comment on

References

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