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. 2017 Aug;102(8):e317-e320.
doi: 10.3324/haematol.2016.162198. Epub 2017 Apr 20.

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma

Isabel J F Hofman  1 , Stephanie Patchett  2 , Mark van Duin  3 , Ellen Geerdens  4   5 , Jelle Verbeeck  1 , Lucienne Michaux  6 , Michel Delforge  7 , Pieter Sonneveld  3 , Arlen W Johnson  2 , Kim De Keersmaecker  8
Affiliations

Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma

Isabel J F Hofman et al. Haematologica. 2017 Aug.
No abstract available

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Figures

Figure 1.
Figure 1.
RPL10 mutations in MM. (A) Linear view of the RPL10 protein with mutations from different cohorts indicated. (B) Chromatograms of mutations found by Sanger sequencing. Germline DNA control, tumor DNA, and tumor cDNA are shown. (C) 3D model of the 60S subunit of the ribosome with RPL10 in blue. In the blow up, the mutant residues I33, E66 and I70 are colored red, green and orange, respectively. (D) Alignment of the RPL10 protein sequence in different species with mutant residues indicated by red stars. (E–F) Functional studies in yeast, testing the effect of the different mutants in Rpl10 on proliferation (E) and polysome profiles (F).
See this image and copyright information in PMC

References

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