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Randomized Controlled Trial
. 2017 Apr 20:14:10.
doi: 10.1186/s12970-017-0169-8. eCollection 2017.

Simple sugar supplementation abrogates exercise-induced increase in hepcidin in young men

Maja Tomczyk  1 , Jakub Kortas  2 , Damian Flis  3 , Wojciech Skrobot  4 , Rafal Camilleri  1 , Jedrzej Antosiewicz  1
Affiliations
Randomized Controlled Trial

Simple sugar supplementation abrogates exercise-induced increase in hepcidin in young men

Maja Tomczyk et al. J Int Soc Sports Nutr. .

Abstract

Background: At present many young people experience too much body iron accumulation. The reason of this phenomenon is not clear. There is accumulating evidences that not proper diet and lack of exercise could be a main contributing factors. This investigation assessed the effects of a diet rich in simple sugars (glucose or fructose) on exercise-induced hepcidin which is hormone regulating iron metabolism.

Methods: A group of physically active young men completed an incremental exercise test before and after a 3-day diet supplemented with fructose (4 g/kg BM) or glucose (4 g/kg BM). After a 1-week break, they crossed over to the alternate mode for the subsequent 3-days period. Venous blood samples were collected before and after 1 h exercise and were analysed for serum hepcidin, IL-6, CRP, iron, and ferritin. The physiological response to exercise was also determined.

Results: The concentration of hepcidin increased 1 h after exercise for the baseline test (p < 0.05), whereas no changes in hepcidin were observed in men whose diet was supplemented with fructose or glucose. Blood IL-6 increased significantly after exercise only in subjects supplemented with fructose. Changes in hepcidin did not correlate with shifts in serum IL-6.

Conclusions: These data suggest that protective effects of exercise on excess iron accumulation in human body which is mediated by hepcidin can be abrogated by high sugar consumption which is typical for contemporary people.

Keywords: CRP; Diet; Ferritin; Iron; Metabolism.

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Figures

Fig. 1
Fig. 1
Schematic presentation of the experimental design
Fig. 2
Fig. 2
Fructose or glucose supplementation abrogates exercise-induced hepcidin. The average level of IL-6 in young men before (I) and 1 h after aerobic test (II) by group of supplementation. Tags represent average values, frames - standard deviations, * - statistically significant differences between (I) and (II), p < 0,05
Fig. 3
Fig. 3
Fructose supplementation augments exercise-induced IL-6. The average level of IL-6 in young men before (I) and 1 h after aerobic test (II) by group of supplementation. Tags represent average values, frames - standard deviations, * - statistically significant differences between (I) and (II), p < 0,05
Fig. 4
Fig. 4
Fructose or glucose supplementation has no effect on CRP. The average level of CRP in young men before (I) and 1 h after aerobic test (II) by group of supplementation. Tags represent average values, frames - standard deviations
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