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. 2017 Apr 21;4(4):CD011917.
doi: 10.1002/14651858.CD011917.pub2.

Surgery for limited-stage small-cell lung cancer

Hayley Barnes  1 , Katharine See  2 , Stephen Barnett  3 , Renée Manser  4
Affiliations

Surgery for limited-stage small-cell lung cancer

Hayley Barnes et al. Cochrane Database Syst Rev. .

Abstract

Background: Current treatment guidelines for limited-stage small-cell lung cancer (SCLC) recommend concomitant platinum-based chemo-radiotherapy plus prophylactic cranial irradiation, based on the premise that SCLC disseminates early, and is chemosensitive. However, although there is usually a favourable initial response, relapse is common and the cure rate for limited-stage SCLC remains relatively poor. Some recent clinical practice guidelines have recommended surgery for stage 1 (limited) SCLC followed by adjuvant chemotherapy, but this recommendation is largely based on the findings of observational studies.

Objectives: To determine whether, in patients with limited-stage SCLC, surgical resection of cancer improves overall survival and treatment-related deaths compared with radiotherapy or chemotherapy, or a combination of radiotherapy and chemotherapy, or best supportive care.

Search methods: We performed searches on CENTRAL, MEDLINE, Embase, CINAHL, and Web of Science up to 11 January 2017. We handsearched review articles, clinical trial registries, and reference lists of retrieved articles.

Selection criteria: We included randomised controlled trials (RCTs) with adults diagnosed with limited-stage SCLC, confirmed by cytology or histology, and radiological assessment, considered medically suitable for resection and radical radiotherapy, which randomised participants to surgery versus any other intervention.

Data collection and analysis: We imported studies identified by the search into a reference manager database. We retrieved the full-text version of relevant studies, and two review authors independently extracted data. The primary outcome measures were overall survival and treatment-related deaths; and secondary outcome measures included loco-regional progression, quality of life, and adverse events.

Main results: We included three trials with 330 participants. We judged the quality of the evidence as very low for all the outcomes. The quality of the data was limited by the lack of complete outcome reporting, unclear risk of bias in the methods in which the studies were conducted, and the age of the studies (> 20 years). The methods of cancer staging and types of surgical procedures, which do not reflect current practice, reduced our confidence in the estimation of the effect.Two studies compared surgery to radiation therapy, and in one study chemotherapy was administered to both arms. One study administered initial chemotherapy, then responders were randomised to surgery versus control; following, both groups underwent chest and whole brain irradiation.Due to the clinical heterogeneity of the trials, we were unable to pool results for meta-analysis.All three studies reported overall survival. One study reported a mean overall survival of 199 days in the surgical arm, compared to 300 days in the radiotherapy arm (P = 0.04). One study reported overall survival as 4% in the surgical arm, compared to 10% in the radiotherapy arm at two years. Conversely, one study reported overall survival at two years as 52% in the surgical arm, compared to 18% in the radiotherapy arm. However this difference was not statistically significant (P = 0.12).One study reported early postoperative mortality as 7% for the surgical arm, compared to 0% mortality in the radiotherapy arm. One study reported the difference in mean degree of dyspnoea as -1.2 comparing surgical intervention to radiotherapy, indicating that participants undergoing radiotherapy are likely to experience more dyspnoea. This was measured using a non-validated scale.

Authors' conclusions: Evidence from currently available RCTs does not support a role for surgical resection in the management of limited-stage small-cell lung cancer; however our conclusions are limited by the quality of the available evidence and the lack of contemporary data. The results of the trials included in this review may not be generalisable to patients with clinical stage 1 small-cell lung cancer carefully staged using contemporary staging methods. Although some guidelines currently recommend surgical resection in clinical stage 1 small-cell lung cancer, prospective randomised controlled trials are needed to determine if there is any benefit in terms of short- and long-term mortality and quality of life compared with chemo-radiotherapy alone.

PubMed Disclaimer

Conflict of interest statement

Hayley Barnes: none known

Katharine See: none known

Stephen Barnett: none known

Renée Manser: none known

Figures

1
1
Study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
See this image and copyright information in PMC

Update of

  • doi: 10.1002/14651858.CD011917

References

References to studies included in this review

Fox 1973 {published data only}
    1. Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small‐celled or oat‐celled carcinoma of bronchus. Ten‐year follow‐up. Lancet 1973;2(7820):63‐5. - PubMed
    1. Miller AB, Fox W, Tall R. Five‐year follow‐up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small‐celled or oat‐celled carcinoma of the bronchus. Lancet 1969;294(7619):501. - PubMed
    1. Scadding JG, Bignall JR, Blair LG. Comparative trial of surgery and radiotherapy for the primary treatment of small‐celled or oatcelled carcinoma of the bronchus: first report to the medical research council by the working party on the evaluation of different methods of therapy in carcinoma of the bronchus. Lancet 1966;288(7471):979‐86. - PubMed
Lad 1994a {published data only}
    1. Lad T, Piantadosi S, Thomas P, Payne D, Ruckdeschel J, Giaccone G. A prospective randomized trial to determine the benefit if surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy. Chest 1994;106(6 Suppl):320S–3S. - PubMed
Liao 1995 {published data only}
    1. Liao M, Zhao J, Zhou Y. Multimodality therapy of late stage lung cancer. Chinese Journal of Oncology 1995;17(5):384‐6. - PubMed

References to studies excluded from this review

Anonymous 1991 {published data only}
    1. Anonymous. Surgery of small cell carcinoma. Kyobu Geka [Japanese Journal of Thoracic Surgery] 1991;39(5):582‐97. - PubMed
Anraku 2006 {published data only}
    1. Anraku M, Waddell TK. Surgery for Small‐Cell Lung Cancer. Seminars in Thoracic and Cardiovascular Surgery 2006;18(3):211‐6. - PubMed
Bychkov 2001 {published data only}
    1. Bychkov MB, Orel NF, Naskhletashvili DR. Present‐day possibilities of the treatment of small cell cancer of the lung. Voprosy Onkologii 2001;47(6):757‐61. - PubMed
Candel 2009 {published data only}
    1. Candel VA, Blesa JMG, Vidal OJ. Treatment of small‐cell lung cancer. Cancer & Chemotherapy Reviews 2009;4(3):131‐40.
Clemente 2013 {published data only}
    1. Clemente M, Soccal PM, Karenovics W, Adler D, Rochat T, Mach N. The role of surgery in early stage small cell lung cancer: Should it be re‐evaluated?. Revue Medicale Suisse 2013;9(407):2172‐4. - PubMed
Coolen 1995 {published data only}
    1. Coolen L, Eeckhout A, Deneffe G, Demedts M, Vansteenkiste J. Surgical treatment of small cell lung cancer. European Journal of Cardio‐thoracic Surgery 1995;9(2):59‐64. - PubMed
Crisci 1989 {published data only}
    1. Crisci C, Nutini S, Righi R, Zottola V, Giannini GM, Camassa M, et al. Role of surgery in undifferentiated small cell carcinoma of the lung. Preliminary results of an international multicenter study. Minerva Chirurgica 1989;44(4):589‐98. - PubMed
Cui 1994 {published data only}
    1. Cui SY, Li HZ, Gu YT. The combined treatment with surgery and chemotherapy: primary approach to small cell lung carcinoma (SCLC). Chung‐Hua Chung Liu Tsa Chih [Chinese Journal of Oncology] 1994;16(6):432‐4. - PubMed
Davis 1993 {published data only}
    1. Davis S, Crino L, Tonato M, Darwish S, Pelicci PG, Grignani F. A prospective analysis of chemotherapy following surgical resection of clinical stage I‐II small‐cell lung cancer. American Journal of Clinical Oncology 1993;16(2):93‐5. - PubMed
de Antonio 2006 {published data only}
    1. Antonio DG, Alfageme F, Gámez P, Córdoba M, Varela A, Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology. Results of surgery in small cell carcinoma of the lung. Lung Cancer (Amsterdam, Netherlands) 2006;52(3):299‐304. - PubMed
Dusmet 2004 {published data only}
    1. Dusmet M, Goldstraw P. Surgery for small cell lung cancer. Hematology/oncology Clinics of North America 2004;18(2):323‐41. - PubMed
Eguchi 1988 {published data only}
    1. Eguchi K. Overview of current studies on the role of surgery of small‐cell carcinoma of the lung. Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):205‐10. - PubMed
Eichhorn 1975 {published data only}
    1. Eichhorn HJ, Eule H, Lessel A, Menne W. Results of a controlled clinical trial for evaluation of intensive preoperative irradiation in operable bronchial cancer. Archiv fur Geschwulstforschung 1975;45(4):376‐84. - PubMed
Elias 1993 {published data only}
    1. Elias AD, Ayash L, Frei E 3rd, Skarin AT, Hunt M, Wheeler C, et al. Intensive combined modality therapy for limited‐stage small‐cell lung cancer. Journal of the National Cancer Institute 1993;85(7):559‐66. - PubMed
Friedberg 2012 {published data only}
    1. Friedberg J, Lotano VE. Role of surgery for small cell lung cancer. Current Problems in Cancer 2012;36(3):117‐30. - PubMed
Fujimori 1997 {published data only}
    1. Fujimori K, Yokoyama A, Kurita Y, Terashima M. A pilot phase 2 study of surgical treatment after induction chemotherapy for resectable stage I to IIIA small cell lung cancer. Chest 1997;111(4):1089‐93. - PubMed
Fujimura 2001 {published data only}
    1. Fujimura S. Limited surgery for bronchogenic carcinoma. Kyobu Geka [Japanese Journal of Thoracic Surgery] 2001;54(8 Suppl):707‐14. - PubMed
Gatzemeier 1986 {published data only}
    1. Gatzemeier U, Radenbach D. Chemotherapy (CAV) and surgical resection as combined modality in the therapy of small‐cell lung cancer. Panminerva Medica 1986;28(2):63‐6. - PubMed
Graham 1993 {published data only}
    1. Graham P. 5‐year actuarial survival results for an admittedly highly selected group of patients with small cell lung cancer treated with surgery and adjuvant chemotherapy. American Journal of Clinical Oncology 1993;16(2):181‐2. - PubMed
Grants 1989 {published data only}
    1. Grants EA, Berzinia V, Bashko I, Zitare I, Berzin'sh I. The results of the adjuvant chemotherapy of patients with small‐cell lung cancer. Voprosy Onkologii 1989;35(2):172‐4. - PubMed
Greschuchna 1978 {published data only}
    1. Greschuchna D. Results of operative therapy for small‐cell bronchogenic carcinoma. Thoraxchirurgie, Vaskulare Chirurgie 1978;26(4):300‐3. - PubMed
Gridelli 1994 {published data only}
    1. Gridelli C, D'Aprile M, Curcio C, Brancaccio L, Palmeri S, Comella G, et al. Carboplatin plus epirubicin plus VP‐16, concurrent 'split course' radiotherapy and adjuvant surgery for limited small cell lung cancer. Gruppo Oncologico Centro‐Sud‐Isole (GOCSI). Lung Cancer 1994;11(1‐2):83‐91. - PubMed
Gridelli 1994a {published data only}
    1. Gridelli C, Ianniello GP, Maiorino A, Curcio C, D'Aprile M, Brancaccio L, et al. Carboplatin, epirubicin, and VP‐16 chemotherapy in the treatment of small cell lung cancer. American Journal of Clinical Oncology 1994;17(2):160‐2. - PubMed
Hansen 1984 {published data only}
    1. Hansen HH. Treatment of small cell carcinoma of the lung. Gan to Kagaku Ryoho. Cancer & Chemotherapy 1984;11(2):171‐85. - PubMed
Hara 1988 {published data only}
    1. Hara N, Motohiro A, Takeo S, Ohtsu Y, Tanaka K, Yamazaki S, et al. Multimodality therapy of small carcinoma of the lung‐‐the role of surgical treatment. Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):190‐4. - PubMed
Hara 1991a {published data only}
    1. Hara N, Ichinose Y, Kuda T, Asoh H, Yano T, Kawasaki M, et al. Long‐term survivors in resected and nonresected small cell lung cancer. Oncology 1991;48(6):441‐7. - PubMed
Hara 1991b {published data only}
    1. Hara N, Ohta M, Ichinose Y, Motohiro A, Kuda T, Asoh H, et al. Influence of surgical resection before and after chemotherapy on survival in small cell lung cancer. Journal of Surgical Oncology 1991;47(1):53‐61. - PubMed
Ju 2012 {published data only}
    1. Ju MH, Kim HR, Kim JB, Kim YH, Kim DK, Park S‐II. Surgical outcomes in small cell lung cancer. The Korean Journal of Thoracic and Cardiovascular Surgery 2012;45(1):40–44. - PMC - PubMed
Karrer 1978 {published data only}
    1. Karrer K, Pridun N, Denck H. Chemotherapy as an adjuvant to surgery in lung cancer. Cancer Chemotherapy and Pharmacology 1978; Vol. 1, issue 3:145‐59. - PubMed
Karrer 1982a {published data only}
    1. Karrer K, Denck H, Pridun N, Zwintz E. Prevention of recurrence of small‐cell lung cancer by adjuvant polychemotherapy. Wiener Klinische Wochenschrift 1982; Vol. 94, issue 7:159‐65. - PubMed
Karrer 1982b {published data only}
    1. Karrer K, Denck H, Pridun N, Zwintz E. Prevention of recurrence of small‐cell lung cancer by adjuvant polychemotherapy. Wiener Klinische Wochenschrift 1982;94(7):159‐65. - PubMed
Karrer 1986 {published data only}
    1. Karrer K, Denck H, Drings P, Orel J, Bruno MF. Combination of surgery and chemotherapy for small‐cell bronchial carcinoma. Drugs under Experimental and Clinical Research 1986;12(1‐3):191‐200. - PubMed
Karrer 1987 {published data only}
    1. Karrer K, Denck H. Multimodality treatment with surgery in small‐cell lung cancer. International Journal of Clinical Pharmacology Research 1987; Vol. 7, issue 4:313‐28. - PubMed
Karrer 1988 {published data only}
    1. Karrer K, Denck H, Karnicka‐Mlodkowska H, Drings P, Erzen J, Dell'Amore D, et al. Surgery for cure followed by combined modality treatment for small cell bronchial carcinoma. ISC Lung Cancer Study Group. International Journal of Clinical Pharmacology Research 1988; Vol. 8, issue 6:415‐21. - PubMed
Karrer 1989a {published data only}
    1. Karrer K, Shields TW, Denck H, Hrabar B, Vogt‐Moykopf I, Salzer GM. The importance of surgical and multimodality treatment for small cell bronchial carcinoma. Journal of Thoracic and Cardiovascular Surgery 1989; Vol. 97, issue 2:168‐76. - PubMed
Karrer 1989b {published data only}
    1. Karrer K, Denck H, Karnicka‐Mlodkowska H, Drings P, Erzen J, Salzer GM, et al. Surgery for cure of small cell bronchial carcinoma (SCLC) at early stages and postoperative combined modality treatment. International Journal of Clinical Pharmacology Research 1989;1(4 Suppl):1207‐8. - PubMed
Karrer 1990 {published data only}
    1. Karrer K, Denck H, Karnicka‐Mlodkowska H, Drings P, Salzer G M, Hrabar B, et al. The importance of surgery as the first step in multimodality treatment of small cell bronchial carcinoma. The ISC Lung Cancer Study Group. International Journal of Clinical Pharmacology Research 1990; Vol. 10, issue 5:257‐63. - PubMed
Karrer 1995 {published data only}
    1. Karrer K, Ulsperger E. Surgery for cure followed by chemotherapy in small cell carcinoma of the lung. For the ISC‐Lung Cancer Study Group. Acta Oncologica 1995;34(7):899‐906. - PubMed
Kobayashi 1988 {published data only}
    1. Kobayashi K, Hashizume N, Horinouchi H, Nakayama M, Kawamura M, Nomori H, et al. The role of surgery in the treatment for small cell lung cancer. Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):200‐4. - PubMed
Kodama 1998 {published data only}
    1. Kodama K, Doi O, Higashiyama M, Yokouchi H, Takami K. Does induction therapy followed by surgery improve the survival rate in limited‐stage small‐cell lung cancer patients?. Nihon Geka Gakkai Zasshi. Journal of Japan Surgical Society 1998;99(5):291‐8. - PubMed
Krishnamurthy 2011 {published data only}
    1. Krishnamurthy J, Tashi T, Gonsalves W, Ganti A K. Treatment of small cell lung cancer. International Journal of Cancer Research and Prevention 2011;4(2):151‐61.
Lad 1991 {published data only}
    1. Lad T, Thomas P, Piantadosi S. Surgical resection of small cell lung cancer ‐ a prospective randomized evaluation [abstract]. Proceedings of the American Society of Clinical Oncology 1991; Vol. 10, issue 244:A835.
Lad 1994b {published data only}
    1. Lad T, Piantadosi S, Thomas P, Payne D, Ruckdeschel J, Giaccone G. A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy. Chest 1994;106(6 Suppl):320S‐3S. - PubMed
Lagerwaard 2010 {published data only}
    1. Lagerwaard FJ. New trials in early disease comparing surgery and radiation. Journal of Thoracic Oncology 2010;1:S24.
Lassen 1999 {published data only}
    1. Lassen U, Hansen HH. Surgery in limited stage small cell lung cancer. Cancer Treatment Reviews 1999;25(2):67‐72. - PubMed
Lewinski 2001 {published data only}
    1. Lewinski T, Zulawski M, Turski C, Pietraszek A. Small cell lung cancer I‐‐III A: cytoreductive chemotherapy followed by resection with continuation of chemotherapy. European Journal of Cardio‐thoracic Surgery 2001;20(2):391‐8. - PubMed
Lexer 1988 {published data only}
    1. Lexer G, Weitensfelder W, Haiderer O, Wieser O. Long‐term survival following pneumonectomy, chemotherapy and radiotherapy in central small cell bronchial cancer. Praxis und Klinik der Pneumologie 1988;42(7):588‐9. - PubMed
Li 2010 {published data only}
    1. Li GH, Wu Y, Zhang XJ, Cui YS. A comparative study of survival time of surgery combined with chemotherapy and non‐surgical chemotherapy in SCLC. Chung‐Hua i Hsueh Tsa Chih [Chinese Medical Journal] 2010; Vol. 90, issue 31:2212‐4. - PubMed
Lucchi 1997 {published data only}
    1. Lucchi M, Mussi A, Chella A, Janni A, Ribechini A, Menconi GF, et al. Surgery in the management of small cell lung cancer. European Journal of Cardio‐thoracic Surgery 1997;12(5):689‐93. - PubMed
Lukianski 1988 {published data only}
    1. Lukianski M. [Surgical treatment of patients with small cell carcinoma of the lungs followed by chemotherapy]. Pneumonologia Polska 1988;56(2):63‐8. - PubMed
Macchiarini 1989a {published data only}
    1. Macchiarini P, Mussi A, Basolo F, Bruno J, Angeletti CA. Optimal treatment for T1‐3NOMO small cell lung cancer: surgery plus adjuvant chemotherapy. Anticancer Research 1989;9(6):1623‐5. - PubMed
Macchiarini 1989b {published data only}
    1. Macchiarini P, Mussi A, Basolo F, Bruno J, Angeletti CA. Optimal treatment for T1‐3N0M0 small cell lung cancer: Surgery plus adjuvant chemotherapy. Anticancer Research 1989;9(6):1623‐6. - PubMed
Namikawa 1988 {published data only}
    1. Namikawa S, Kusagawa K, Tani K, Kanamori Y, Higashi K, Takeuchi Y, et al. The role of surgical resection and the effect of neo‐adjuvant therapy in the management of small cell lung cancer (SCLC). Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):195‐9. - PubMed
Osterlind 1986a {published data only}
    1. Osterlind K, Hansen HH, Hansen M, Dombernowsky P. Mortality and morbidity in long‐term surviving patients treated with chemotherapy with or without irradiation for small‐cell lung cancer. Journal of Clinical Oncology 1986;4(7):1044‐52. - PubMed
Osterlind 1986b {published data only}
    1. Osterlind K, Hansen M, Hansen HH, Dombernowsky P. Influence of surgical resection prior to chemotherapy on the long‐term results in small cell lung cancer. A study of 150 operable patients. European Journal of Cancer & Clinical Oncology 1986;22(5):589‐93. - PubMed
Prager 1984 {published data only}
    1. Prager RL, Foster JM, Hainsworth JD, Hande KR, Johnson DH, Wolff SN, et al. The feasibility of adjuvant surgery in limited‐stage small cell carcinoma: a prospective evaluation. Annals of Thoracic Surgery 1984;38(6):622‐6. - PubMed
Rea 1998 {published data only}
    1. Rea F, Callegaro D, Favaretto A, Loy M, Paccagnella A, Fantoni U, et al. Long term results of surgery and chemotherapy in small cell lung cancer. European Journal of Cardio‐thoracic Surgery 1998;14(4):398‐402. - PubMed
Schamanek 1994 {published data only}
    1. Schamanek A, Karrer K. Importance of surgery in the multimodality treatment for small cell lung cancer (SCLC). Radiology and Oncology 1994;28(4):351‐8.
Shepherd 1983 {published data only}
    1. Shepherd FA, Ginsberg RJ, Evans WK. Reduction in local recurrence and improved survival in surgically treated patients with small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery 1983;86(4):498‐506. - PubMed
Shepherd 1989 {published data only}
    1. Shepherd FA, Ginsberg RJ, Patterson GA, Evans WK, Feld R. A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer. A University of Toronto Lung Oncology Group study. Journal of Thoracic and Cardiovascular Surgery 1989;97(2):177‐86. - PubMed
Shepherd 1991 {published data only}
    1. Shepherd FA, Ginsberg RJ, Feld R, Evans WK, Johansen E. Surgical treatment for limited small‐cell lung cancer. The University of Toronto Lung Oncology Group experience. Journal of Thoracic and Cardiovascular Surgery 1991;101(3):385‐93. - PubMed
Sorenson 1981 {published data only}
    1. Sorenson S. Treatment of small cell carcinoma of the lung. European Journal of Respiratory Diseases 1981;62(5):315‐31. - PubMed
Szczesny 2003 {published data only}
    1. Szczesny TJ, Szczesna A, Shepherd FA, Ginsberg RJ. Surgical treatment of small cell lung cancer. Seminars in Oncology 2003;30(1):47‐56. - PubMed
Theuer 1992 {published data only}
    1. Theuer W, Selawry O, Karrer K. The impact of surgery on the multidisciplinary treatment of bronchogenic small cell carcinoma. (Updated review including ongoing studies). Medical Oncology and Tumor Pharmacotherapy 1992; Vol. 9, issue 3:119‐37. - PubMed
Tsuchiya 2005 {published data only}
    1. Tsuchiya R, Suzuki K, Ichinose Y, Watanabe Y, Yasumitsu T, Ishizuka N, et al. Phase II trial of postoperative adjuvant cisplatin and etoposide in patients with completely resected stage I‐IIIa small cell lung cancer: the Japan Clinical Oncology Lung Cancer Study Group Trial (JCOG9101). Journal of Thoracic and Cardiovascular Surgery 2005;129(5):977‐83. - PubMed
Ulsperger 1990 {published data only}
    1. Ulsperger E, Karrer K, Shields TW. Surgery for cure followed by multimodality treatment for small cell bronchial carcinoma (SCLC). Annals of Oncology 1990; Vol. 1, issue Suppl:51.
Ulsperger 1991 {published data only}
    1. Ulsperger E, Karrer K, Denck H. Multimodality treatment for small cell bronchial carcinoma. Preliminary results of a prospective, multicenter trial. The ISC‐Lung Cancer Study Group. European Journal of Cardio‐thoracic Surgery 1991;5(6):306‐9; discussion 310. - PubMed
Veronesi 2007 {published data only}
    1. Veronesi G, Scanagatta P, Leo F, Pas T, Pelosi G, Catalano G, et al. Adjuvant surgery after carboplatin and VP16 in resectable small cell lung cancer. Journal of Thoracic Oncology 2007;2(2):131‐4. - PubMed
Watanabe 1988 {published data only}
    1. Watanabe Y, Kimoto H, Shimizu J, Murakami N, Oda M, Yoshida M, et al. [The role of surgery in the management of small cell carcinoma of the lung]. Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):178‐83. - PubMed
Yamaguchi 1988 {published data only}
    1. Yamaguchi Y, Momiki S, Kimura H, Ogawa T, Baba M. The role of surgical treatment in the combination therapy of small cell lung cancer (SCLC). Kyobu Geka [Japanese Journal of Thoracic Surgery] 1988;41(3):184‐9. - PubMed

Additional references

AIHW & AACR 2012
    1. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: an overview (Cancer series no. 74. Cat. no. CAN 70. Canberra: AIHW). www.aihw.gov.au/WorkArea/DownloadAsset.aspx?id=60129542353 (accessed 24 May 2014).
Badzio 2004
    1. Badzio A, Kurowski K, Karnicka‐Mlodkowska H, Jassem J. A retrospective study of surgery followed by chemotherapy vs. Non‐surgical management in limited‐disease small cell lung cancer. European Journal of Cardio‐thoracic Surgery 2004;26(1):183‐8. - PubMed
Brock 2005
    1. Brock M, Hooker C, Syphard J, Westra W, Xu L, Alberg AJ, et al. Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come. Journal of Thoracic and Cardiovascular Surgery 2005;129(1):64‐72. - PubMed
Goldstraw 2007
    1. Goldstraw P, Crowley J, Chansky K, Diroux DJ, Groome PA, Rami‐Porta R, et al. The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groups in the forthcoming (seventh) edition of the TNM classification of malignant tumours. Journal of Thoracic Oncology 2007;2(8):706. - PubMed
GradePro 2015 [Computer program]
    1. McMaster University (developed by Evidence Prime, Inc.) 2015. GRADEpro GuidelineDevelopment Tool [Software].. Available from www.gradepro.org. McMaster University (developed by Evidence Prime, Inc.), 2015.
Higgins 2011
    1. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Jett 2013
    1. Jett JR, Schild SE, Kesler KA, Kalemkerian GP. Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd edition: American College of Chest Physicians evidence‐based clinical practice guidelines. Chest 2013;143(5 Suppl):e400S‐19S. - PubMed
Lim 2008
    1. Lim, E, Belcher E, Yap, Y, Nicholson A, Goldstraw P. The role of surgery in the treatment of limited disease small cell lung cancer: time to reevaluate. Journal of Thoracic Oncology 2008;3(11):1267–71. - PubMed
Manser 2005
    1. Manser R, Wright G, Hart D, Byrnes G, Campbell D, Wainer Z, al. Surgery for local and locally advanced non‐small cell lung cancer. Cochrane Database of Systematic Reviews 2005, Issue 1. [DOI: 10.1002/14651858.CD004699.pub2] - DOI - PMC - PubMed
Miller 1969
    1. Miller AB, Fox W, Tall R. Five‐year follow‐up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small‐celled or oat‐celled carcinoma of the bronchus. Lancet 1969;2(7619):501‐5. - PubMed
NCCN 2015
    1. National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Small Cell Lung Cancer. Version 2. 2015. www.nccn.org/professionals/physician_gls/f_guidelines.asp (accessed 24 May 2015).
NCI CTCAE 2010
    1. National Cancer Institute. Common Terminology Criteria for Adverse Events. evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010‐06‐14_QuickReference_5x7.pdf (accessed 24 May 2015).
NHMRC 2004
    1. National Health and Medical Research Council (NHMRC). Clinical Practice Guidelines for the Prevention, Diagnosis and Management of Lung Cancer. www.nhmrc.gov.au/guidelines‐publications/cp97 (accessed 24 May 2015).
NHMRC 2015
    1. Cancer Council Australia Lung Cancer Guidelines Working Party. Clinical practice guidelines for the treatment of lung cancer. Sydney: Cancer Council Australia. [Version URL: wiki.cancer.org.au/australiawiki/index.php?oldid=99968. Available from: wiki.cancer.org.au/australia/Guidelines:Lung_cancer (accessed 24 May 2015).
NICE 2011
    1. National Institute for Health and Clinical Excellence (NICE). NICE clinical guideline 121 — Lung cancer: The diagnosis and treatment of lung cancer. www.nice.org.uk/guidance/cg121 (accessed 24 May 2015).
Powell 2009
    1. Powell ES, Pearce AC, Cook D, Davies P, Bishay E, Bowler GM, et al. UK pneumonectomy outcome study (UKPOS): a prospective observational study of pneumonectomy outcome. Journal of Cardiothoracic Surgery 2009;4:41. - PMC - PubMed
Review Manager 2014 [Computer program]
    1. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
Rostad 2004
    1. Rostad H, Naalsund A, Jacobsen R, Strand T, Scott H, Strom E, et al. Small cell lung cancer in Norway. Should more patients have been offered surgical therapy?. European Journal of Cardiothoracic Surgery 2004;26(4):782‐6. - PubMed
Scadding 1966
    1. Scadding JG, Bignall JR, Blair LG. Comparative trial of surgery and radiotherapy for the primary treatment of small‐celled or oatcelled carcinoma of the bronchus: first report to the medical research council by the working party on the evaluation of different methods of therapy in carcinoma of the bronchus. Lancet 1966;288(7471):979‐86. - PubMed
Shepherd 2007
    1. Shepherd F, Crowley J, Houtte P, Postmus P, Carney D, et al. International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions. The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals Regarding the Clinical Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the Tumor, Node, Metastasis Classification for Lung Cancer. Journal of Thoracic Oncology 2007;2(12):1067–77. - PubMed
Stahel 1989
    1. Stahel R, Ginsberg R, Havemann K, Hirsch FR, Ihde DC, Jassem J, et al. Staging and prognostic factors in small cell lung cancer: a consensus report. Lung Cancer 1989;5:119–26.
Travis 2011
    1. Travis W, Brambilla E, Noguchi M, Nicholson A, Geisinger K, Yatabe Y, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. Journal of Thoracic Oncology 2011;6(2):244‐85. - PMC - PubMed
Travis 2013
    1. Travis W, Brambilla E, Riely G. New Pathologic Classification of Lung Cancer: Relevance for Clinical Practice and Clinical Trials. Journal of Clinical Oncology 2013;31(8):992‐1001. - PubMed
Vallieres 2009
    1. Vallieres E, Shepherd FA, Crowley J, Houtte P, Postmus PE, Carney D, et al. The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. Journal of Thoracic Oncology 2009;4(9):1049‐59. - PubMed
van Meerbeeck 2011
    1. Meerbeeck JP, Fennell DA, Ruysscher DM. Small‐cell lung cancer. Lancet 2011;378(9804):1741–55. - PubMed
Watson 1962
    1. Watson WL, Berg JW. Oat cell lung cancer. Cancer 1962;15:759‐68. - PubMed
Yu 2010
    1. Yu J, Decker R, Detterbeck F, Wilson L. Surveillance epidemiology and end results evaluation of the role of surgery for stage I small cell lung cancer. Journal of Thoracic Oncology 2010;5(2):215‐9. - PubMed
Zelen 1973
    1. Zelen M. Keynote address on biostatistics and data retrieval. Cancer Chemotherapy Reports. Part 3 1973;4(2):31–42. - PubMed

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