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. 2017 May 15;56(10):5757-5761.
doi: 10.1021/acs.inorgchem.7b00359. Epub 2017 Apr 21.

Hafnium-Based Contrast Agents for X-ray Computed Tomography

Markus Berger  1 , Marcus Bauser  1 , Thomas Frenzel  1 , Christoph Stephan Hilger  1 , Gregor Jost  1 , Silvia Lauria  2 , Bernd Morgenstern  2 , Christian Neis  2 , Hubertus Pietsch  1 , Detlev Sülzle  1 , Kaspar Hegetschweiler  2
Affiliations

Hafnium-Based Contrast Agents for X-ray Computed Tomography

Markus Berger et al. Inorg Chem. .

Abstract

Heavy-metal-based contrast agents (CAs) offer enhanced X-ray absorption for X-ray computed tomography (CT) compared to the currently used iodinated CAs. We report the discovery of new lanthanide and hafnium azainositol complexes and their optimization with respect to high water solubility and stability. Our efforts culminated in the synthesis of BAY-576, an uncharged hafnium complex with 3:2 stoichiometry and broken complex symmetry. The superior properties of this asymmetrically substituted hafnium CA were demonstrated by a CT angiography study in rabbits that revealed excellent signal contrast enhancement.

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