Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr 25;8(17):28758-28768.
doi: 10.18632/oncotarget.15672.

Outcomes of microwave ablation for hepatocellular carcinoma adjacent to large vessels: a propensity score analysis

Jian-Ping Dou  1 , Jie Yu  1 , Xiao-Huan Yang  1 , Zhi-Gang Cheng  1 , Zhi-Yu Han  1 , Fang-Yi Liu  1 , Xiao-Ling Yu  1 , Ping Liang  1
Affiliations

Outcomes of microwave ablation for hepatocellular carcinoma adjacent to large vessels: a propensity score analysis

Jian-Ping Dou et al. Oncotarget. .

Abstract

The aim of this study was to retrospectively compare the long-term efficacy of MW ablation as a curative therapy for hepatocellular carcinoma(HCC) adjacent to large vessels(≥3 mm) with that in safe location. Between 2010 and 2016, 406 patients diagnosed with early-stage HCC at Chinese PLA general hospital were enrolled. One-to-one matched pairs between the vessel group and the safe group were generated using propensity score matching. The associations of treatment strategy with overall survival and local tumor progression were determined by Cox regression. Before matching, 113 patients were classified into the vessel group and 293 patients were classified into the vessel group. The patients in the vessel group were more frequently classified as larger tumor size (P<0.05) and higher AFP level (P<0.05) than patients in the safe group. After propensity score matching, 113 pairs of well-matched HCC patients were selected from different treatment groups. No significant differences were found in local tumor progression, overall survival and complication rates for MW ablation as a first-line treatment for the early-stage HCC between two groups. In conclusion, MW ablation provides an effective and safe way to treat early-stage HCC adjacent to large vessels.

Keywords: hepatocellular carcinoma; microwave ablation; prognosis; propensity score matching; vessel.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure1
Figure1. Kaplan–Meier curves of HCC patients with different tumor location
(A) overall survival before matching; (B) overall survival after matching. (C) local tumor progression before matching; (D) local tumor progression after matching.
Figure1
Figure1. Kaplan–Meier curves of HCC patients with different tumor location
(A) overall survival before matching; (B) overall survival after matching. (C) local tumor progression before matching; (D) local tumor progression after matching.
Figure 2
Figure 2. Histograms with overlaid kernel density estimates of standardized differences before and after matching
Standardized differences were centralized around zero, indicating a good matching.
See this image and copyright information in PMC

References

    1. Maluccio M, Covey A. Recent Progress in Understanding, Diagnosing, and Treating Hepatocellular Carcinoma. CA Cancer J Clin. 2012(62):394–9. - PubMed
    1. Forner A, Llovet JM, Bruix J. Hepatocellular carcinoma. Lancet. 2012;379:1245–55. - PubMed
    1. Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, Chen MH, Choi BI, de Baère T, Dodd GD, 3rd, Dupuy DE, Gervais DA, Gianfelice D, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update. Radiology. 2014;273:241–60. - PMC - PubMed
    1. Berber E, Siperstein A. Local recurrence after laparoscopic radiofrequency ablation of liver tumors: an analysis of 1032 tumors. Ann Surg Oncol. 2008;15:2757–2764. - PubMed
    1. Chiang J, Cristescu M, Lee MH, Moreland A, Hinshaw JL, Lee FT, Brace CL. Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma. Radiology. 2016(281):617–624. - PMC - PubMed

MeSH terms