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Editorial
. 2017 May 16;8(20):32382-32383.
doi: 10.18632/oncotarget.16636.

PINK1 and Ataxin-2 as modifiers of growth

Nesli E Sen  1 , Suzana Gispert  1 , Georg Auburger  1
Affiliations
Editorial

PINK1 and Ataxin-2 as modifiers of growth

Nesli E Sen et al. Oncotarget. .
No abstract available

Keywords: motor neuron disease; neuroblastoma regression; obesity; tumor suppressor.

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Figures

Figure 1
Figure 1. Two sides of each coin
Neuronal atrophy and tumor regression are triggered by a gain of Ataxin-2 function, while Ataxin-2 deficiency is responsible for obesity and neuroprotection. PINK1 is also responsible for neurodegeneration when its function is deficient, while a gain of PINK1 function acts as tumor suppressor.
See this image and copyright information in PMC

References

    1. Sen NE, et al. Neurobiol Dis. 2016;96:115–126. - PubMed
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    1. Auburger G, et al. World J Diabetes. 2014;5:316–327. - PMC - PubMed
    1. Lastres-Becker I, et al. Hum Mol Genet. 2008;17:1465–1481. - PubMed

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