doi: 10.1128/AAC.32.6.922.
Clinical isolate of Citrobacter freundii highly resistant to new quinolones
Affiliations
- PMID: 2843087
- PMCID: PMC172307
- DOI: 10.1128/AAC.32.6.922
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Clinical isolate of Citrobacter freundii highly resistant to new quinolones
Antimicrob Agents Chemother.
1988 Jun.
Abstract
About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.
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