Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;32(6):922-4.
doi: 10.1128/AAC.32.6.922.

Clinical isolate of Citrobacter freundii highly resistant to new quinolones

H Aoyama  1 , K Fujimaki, K Sato, T Fujii, M Inoue, K Hirai, S Mitsuhashi
Affiliations

Clinical isolate of Citrobacter freundii highly resistant to new quinolones

H Aoyama et al. Antimicrob Agents Chemother. 1988 Jun.

Abstract

About 30% of 150 recent clinical isolates of Citrobacter freundii were resistant to greater than or equal to 3.13 micrograms of norfloxacin and ofloxacin per ml. Study of one quinolone-resistant strain for which the norfloxacin MIC was 100 micrograms/ml suggested that resistance was associated with both an altered A subunit of DNA gyrase and reduction in drug uptake accompanied by a decrease in an outer membrane protein.

PubMed Disclaimer

References

    1. J Bacteriol. 1969 Jul;99(1):238-41 - PubMed
    1. Antimicrob Agents Chemother. 1988 Jan;32(1):104-9 - PubMed
    1. Biochim Biophys Acta. 1975 Dec 1;413(2):163-76 - PubMed
    1. J Bacteriol. 1978 Mar;133(3):1181-9 - PubMed
    1. J Bacteriol. 1978 Mar;133(3):1478-83 - PubMed

MeSH terms

Substances

LinkOut - more resources