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Comment
. 2017 Feb 1;158(2):229-232.
doi: 10.1210/en.2016-1884.

Spatiotemporal Regulation of Insulin-Like Growth Factor-1 and Its Receptor in the Brain: Is There a Role for Growth Hormone?

Sarah M Gray  1 , Michael O Thorner  2
Affiliations
Comment

Spatiotemporal Regulation of Insulin-Like Growth Factor-1 and Its Receptor in the Brain: Is There a Role for Growth Hormone?

Sarah M Gray et al. Endocrinology. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic of growth hormone and IGF-1 axis. At the hypothalamus, GHRH and somatostatin (SS) regulate GH release from the anterior pituitary. GH action at the liver stimulates IGF-1 secretion, which can act on peripheral tissues. Ghrelin is secreted from the stomach and promotes GH secretion through direct action at the pituitary or indirectly through its actions on hypothalamic regulatory hormones. Circulating IGF-1 from the liver enters the hippocampus and has actions described by Trueba-Saiz et al. (10). It is unknown how circulating GH, ghrelin, or IGF-1 may affect hippocampal GH or GH-R. It is also unknown how circulating GH and ghrelin may affect the pathway described by Trueba-Saiz et al. (10). Canonical signaling cascades are shown with solid lines. An arrowhead indicates stimulation, and a bar-headed lines indicates inhibition. Unknown actions of hippocampal GH and GH-R are surrounded by dashed lines. Additionally, unknown signaling cascades are indicated by dashed lines.
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