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Review
. 2017 Jun 1;215(11):1666-1672.
doi: 10.1093/infdis/jix186.

Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality From Diarrhea

Eleanor Burnett  1 , Christine L Jonesteller  1 , Jacqueline E Tate  2 , Catherine Yen  2 , Umesh D Parashar  2
Affiliations
Review

Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality From Diarrhea

Eleanor Burnett et al. J Infect Dis. .

Abstract

In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.

Keywords: Rotavirus vaccine; diarrhea; rotavirus.

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Conflict of interest statement

Disclaimer: The authors have no funding or conflicts of interest to disclose.

The authors either do not have a commercial or other association that might pose a conflict of interest;

Figures

Figure 1
Figure 1
Map of rotavirus vaccine national introductions and estimates of rotavirus vaccine impact by individual countries.
Figure 2
Figure 2
Article review and selection process.
Figure 3
Figure 3
Reduction in AGE hospitalizations by age group and country's child mortality strata
Figure 4
Figure 4
Reduction in AGE deaths by age group and country's child mortality strata
Figure 5
Figure 5
Percentage of specimens positive for rotavirus by age group
Figure 6
Figure 6
A. Reduction in AGE hospitalizations by age group and country's child mortality strata over time B. Reduction in rotavirus hospitalizations by age group and country's child mortality strata over time
Figure 7
Figure 7
a. Reduction in AGE hospitalizations by age group in the first full year after vaccine introduction. b. Reduction in rotavirus hospitalizations by age group in the first full year after vaccine introduction
See this image and copyright information in PMC

Comment in

References

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