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Comment
. 2017 Aug 1;81(2):E16-E18.
doi: 10.1093/neuros/nyx202.

Letter: Extensive Migration of Young Neurons Into the Infant Human Frontal Lobe

Adriano Barreto Nogueira  1   2 , Ariel Barreto Nogueira  3 , José Carlos Esteves Veiga  2 , Manoel Jacobsen Teixeira  1   4
Affiliations
Comment

Letter: Extensive Migration of Young Neurons Into the Infant Human Frontal Lobe

Adriano Barreto Nogueira et al. Neurosurgery. .
No abstract available

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Figures

FIGURE.
FIGURE.
Connections between hypothalamus zones that express neurogenesis markers and migratory routes of immature interneurons in the frontal lobe. Panel A shows that the counterpart locations of the medial ganglionic eminence (MGE) in the adult mammalian brain (structures in yellow; reprinted with permission from O’Connell and Hofmann) are anterior (left-hand figure) and superior (right-hand figure) to the hypothalamus (hy), including the preoptic area (poa). Panel B is a sagittal view of an adult human brain specimen (adapted from Nogueira et al). The zone underneath the green ellipse encompasses adult counterpart locations of MGE, which display a dense DCX expression in the infant brain., This zone overlaps partially with the zone of the septal area and anterior hypothalamus (yellow ellipse), which expresses neurogenesis markers in the adult human brain. Note that the paraolfactory (po) and paraterminal (pt) gyri are regarded part of the septal area. The neural circuit formed from the mammillothalamic tract to the anterior thalamic nuclei (yellow arrow) and next to the anterior cingulate gyrus (cg; green arrow), expresses neurogenesis markers in the postnatal human brain. Panel C is an immunohistochemistry image of glial fibrillary acid protein stained in red and DAPI stained in blue in a coronal slice of the body of the lateral ventricle (lv; adapted from Nogueira et al). This figure illustrates that the zone encompassing the choroid plexus (cp), fornix (fx), and subcallosal zone (scz), which expresses neurogenesis markers in adults, reaches the adult counterpart location of the infant brain zone referred to as Arc,, from which immature interneurons migrate toward the cingulate gyrus. Legend: ac, anterior commissure; bcn, body of the caudate nucleus; BNST, bed nucleus of the stria terminalis; cc, corpus callosum; cf, column of the fornix; fm, forame of Monro; ic, internal capsule; LS, lateral septum; mb, mammillary body; NAcc, nucleus accumbens; oc, optic chiasm; sg, straight gyrus; sp, septum pellucidus; st, stria terminalis; Str, striatum; th, thalamus; VP, ventral pallidum. Scale bar: 5000 μm.
See this image and copyright information in PMC

Comment on

References

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