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. 2017 May 15;215(10):1523-1526.
doi: 10.1093/infdis/jix188.

Cytomegalovirus Kinetics Following Primary Infection in Healthy Women

Michael S Forman  1 , Dhananjay Vaidya  2   3 , Oluwaseyi Bolorunduro  4 , Marie Diener-West  4 , Robert F Pass  5 , Ravit Arav-Boger  6
Affiliations

Cytomegalovirus Kinetics Following Primary Infection in Healthy Women

Michael S Forman et al. J Infect Dis. .

Abstract

The kinetics of cytomegalovirus (CMV) DNA in infected asymptomatic hosts are largely unknown. We measured viral load (VL) in 124 fluid samples (oral, urine, vaginal, blood) collected from 21 women who acquired CMV. A quantitative real-time polymerase chain reaction assay of US17, which correlated with clinical assays, was used. VL decreased following primary infection in all fluids. The geometric mean VL of vaginal fluid was significantly higher than that of other sources: oral (3.89; 95% confidence interval [CI], 1.43-10.57), urine (6.36; 95% CI, 2.48-16.32), and whole blood (11.88; 95% CI, 4.12-34.20). Vaginal CMV shedding may provide a route for sexual and possibly perinatal transmission.

Keywords: Cytomegalovirus; US17 real-time PCR.; normal host; viral loads.

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Figures

Figure 1.
Figure 1.
Distribution of the geometric mean of viral load measurements by the 4 fluid compartments at T1 (A) and T2 (B) time intervals. The median and interquartile range are shown on these box plots. Outliers are indicated by dots.
See this image and copyright information in PMC

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