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Review
. 2018 Mar 1;10(3):a029421.
doi: 10.1101/cshperspect.a029421.

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

Federica Sallusto  1   2 , Antonino Cassotta  1   2 , Daniel Hoces  1 , Mathilde Foglierini  1 , Antonio Lanzavecchia  1
Affiliations
Review

Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? T-Cell Heterogeneity, Plasticity, and Selection in Humans

Federica Sallusto et al. Cold Spring Harb Perspect Biol. .

Abstract

The wide range of effector and memory T cells is instrumental for immune regulation and tailored mechanisms of protection against pathogens. Here, we will focus on human CD4 T cells and discuss T-cell plasticity and intraclonal diversification in the context of a progressive and selective model of CD4 T-cell differentiation.

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Figures

Figure 1.
Figure 1.
Two types of human TH1 cells. CXCR3+CCR6− TH1 cells expressing T-bet are preferentially elicited by viruses, whereas CXCR3+CCR6+ TH1* cells expressing T-bet and RORγt are preferentially elicited by bacteria, possibly by different polarizing cytokines present at sites of induction. IFN, Interferon; IL, interleukin.
Figure 2.
Figure 2.
Graphical representation of the extent of sharing among T-cell antigen receptor (TCR) clonotypes of memory TH1 (red), TH2 (yellow), TH1* (blue), and TH17 (green) cells primed by Candida albicans (A), or tetanus toxoid (B). Outer rings and connecting lines identify clonotypes shared between two or more T-cell subsets. Data are representative of single donors. (From Becattini et al. 2015; modified, with permission.)
See this image and copyright information in PMC

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