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Meta-Analysis
. 2017 Apr 21;7(1):1012.
doi: 10.1038/s41598-017-00978-z.

Laparoscopic Versus Open Liver Resection for Colorectal Liver Metastases: A Comprehensive Systematic Review and Meta-analysis

Si-Ming Xie  1   2 , Jun-Jie Xiong  3 , Xue-Ting Liu  4 , Hong-Yu Chen  3 , Daniel Iglesia-García  5 , Kiran Altaf  5 , Shameena Bharucha  5 , Wei Huang  5 , Quentin M Nunes  5 , Peter Szatmary  6 , Xu-Bao Liu  7
Affiliations
Meta-Analysis

Laparoscopic Versus Open Liver Resection for Colorectal Liver Metastases: A Comprehensive Systematic Review and Meta-analysis

Si-Ming Xie et al. Sci Rep. .

Erratum in

Abstract

The effects of laparoscopic liver resection (LLR) and open liver resection (OLR) on oncological outcomes for colorectal cancer liver metastases (CCLM) remain inconclusive. Major databases were searched from January 1992 to October 2016. Effects of LLR vs OLR were determined. The primary endpoints were oncological outcomes. In total, 32 eligible non-randomized studies with 4697 patients (LLR: 1809, OLR: 2888) were analyzed. There were higher rates of clear surgical margins (OR: 1.64, 95%CI: 1.32 to 2.05, p < 0.00001) in the LLR group, without significant differences in disease recurrence, 3- or 5-year overall survival(OS) and disease free survival(DFS) between the two approaches. LLR was associated with less intraoperative blood loss (WMD: -147.46 [-195.78 to -99.15] mL, P < 0.00001) and fewer blood transfusions (OR: 0.41 [0.30-0.58], P < 0.00001), but with longer operation time (WMD:14.44 [1.01 to 27.88] min, P < 0.00001) compared to OLR. Less overall morbidity (OR: 0.64 [0.55 to 0.75], p < 0.00001) and shorter postoperative hospital stay (WMD: -2.36 [-3.06 to -1.66] d, p < 0.00001) were observed for patients undergoing LLR, while there was no statistical difference in mortality. LLR appears to be a safe and feasible alternative to OLR in the treatment of CCLM in selected patients.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Study selection flow chart according to PRISMA statement.
Figure 2
Figure 2
(A) Forest plot of negative surgical margin between two groups. (B) Forest plot of recurrence between two groups. (C). Forest plot of 3-year OS between two groups. (D) Forest plot of 5-year OS between two groups. (E) Forest plot of 3-year DFS between two groups. (F) Forest plot of 5-year DFS between two groups.
Figure 3
Figure 3
Funnel plots for publication bias. The funnel plot revealed no publication bias. (A) 3-OS; (B) 5-OS; (C) overall morbidity.
See this image and copyright information in PMC

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