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Comment
. 2017 May 3;25(5):1064-1066.
doi: 10.1016/j.ymthe.2017.04.012. Epub 2017 Apr 19.

Sensing Bad: Are Co-stimulatory CAR-Expressing γδ T Cells Safer?

Robin Parihar  1
Affiliations
Comment

Sensing Bad: Are Co-stimulatory CAR-Expressing γδ T Cells Safer?

Robin Parihar. Mol Ther. .
No abstract available

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Figures

Figure 1
Figure 1
“Co-stimulation Only” CAR-γδ T Cell Activation after Recognition of Two Separate Tumor-Associated Molecules The cytotoxic capacity of CD3ζ (signal 1) is mediated through the native γδ-TCR recognizing the tumor-associated danger signal, IPP, while co-stimulation (signal 2) is provided by a CAR recognizing the GD2 solid tumor antigen with an endodomain consisting of the innate NKG2D signaling molecule, DAP10. Normal healthy tissue does not express IPP and thus does not activate γδ T cells through their TCR.
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