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. 2017 Mar;24(sup1):74-75.
doi: 10.1080/13506129.2017.1295377.

A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid

Shannon P Beierle  1 , James S Foster  2 , Tina Richey  2 , Alan Stuckey  3 , Sallie Macy  2 , Stephen J Kennel  2   3 , Jonathan S Wall  2   3
Affiliations

A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid

Shannon P Beierle et al. Amyloid. 2017 Mar.
No abstract available

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Conflict of interest statement

Declaration of interest

The authors report no conflicts of interest.

Figures

Figure 1.
Figure 1.
Synthetic λ6 fibrils surgically implanted into a mouse liver are detectable using radiolabeled amyloid-reactive peptides. The rVλ6 amyloid mass was visible in the liver by using Congo red and immunohistochemically using anti-λ6 antibodies. SPECT/CT imaging of the mouse following IV injection of 125I-p5 + 14 peptide revealed uptake in a focal lesion in the liver, consistent with the presence of amyloid. Mouse was 5 days post-surgery. Original magnification 160×.
See this image and copyright information in PMC

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