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. 2017 Apr 10:10:2069-2075.
doi: 10.2147/OTT.S129653. eCollection 2017.

Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients

Chun-Chieh Huang  1   2 , Fu-Min Fang  1 , Hui-Chun Chen  1 , Hsuan-Chih Hsu  1 , Tai-Lin Huang  3 , Yu-Li Su  3 , Ya-Chun Chang  4
Affiliations

Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients

Chun-Chieh Huang et al. Onco Targets Ther. .

Abstract

Purpose: Cranial nerve (CN) palsy is the main symptom in patients with locally advanced nasopharyngeal carcinoma (NPC). This study aimed to evaluate the therapeutic outcome of NPC with CN palsy and to analyze the prognostic factors.

Patients and methods: A total of 104 NPC patients with CN palsy curatively treated by conventional (n=44) or conformal (n=60) radiotherapy (RT) were enrolled. Upper CN palsy was present in 81 patients, lower CN palsy in four patients, and both upper and lower CN palsy in 19 patients. Forty-one patients had CN palsy for >2 months before diagnosis.

Results: Complete recovery of CN palsy was observed in 74 patients. The actuarial 5-year locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 58.2%, 62.2%, and 38.4%, respectively. No significant difference was observed in CN recovery, LRC, DMFS, or OS for patients treated by conventional versus conformal technique. However, significant reduction of grade 3 or greater toxicities was found in those treated by the conformal technique (odds ratio =0.28).

Conclusion: Patients with CN palsy presenting >2 months before diagnosis were hard to recover from palsy. The LRC, OS, and recovery from CN palsy did not significantly change with the treatment evolution. Patients with complete recovery from CN palsy had longer OS.

Keywords: cranial nerve palsy; nasopharyngeal carcinoma; radiotherapy.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
OS between conventional RT and conformal RT groups. Abbreviations: OS, overall survival; RT, radiotherapy.
Figure 2
Figure 2
Better OS rate in patients with complete recovery of cranial palsy. Abbreviations: OS, overall survival; CN, cranial nerve.
Figure 3
Figure 3
Lower cumulative incidence rate of toxicity in conformal RT group. Abbreviation: RT, radiotherapy.
See this image and copyright information in PMC

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