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. 1979 Jan;76(1):377-80.
doi: 10.1073/pnas.76.1.377.

Monoclonal antibodies reacting with murine teratocarcinoma cells

P N Goodfellow, J R Levinson, V E Williams 2nd, H O McDevitt

Monoclonal antibodies reacting with murine teratocarcinoma cells

P N Goodfellow et al. Proc Natl Acad Sci U S A. 1979 Jan.

Abstract

Monoclonal antibodies were produced in vitro by fusing mouse myeloma cells with spleen cells from a rat immunized with the C3H mouse teratocarcinoma C86-S1. After the fusion two clones were chosen for further analysis. The first clone, 3C4-10, produced an antibody recognizing an antigen with a distribution restricted to teratocarcinoma cell lines, an endoderm cell line, and a neuroblastoma. The second clone, 4A1-9, produced an antibody that reacted with all cultured murine cells tested and adult brain. Neither antibody reacted with preimplantation embryos. The 3C4-10 antibody recognized an antigen associated with proteins. The apparent molecular weight of the 3C4-10 antigen was greater than 100,000.

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References

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