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Review
. 2017 Mar 29:10:77-84.
doi: 10.2147/IJNRD.S103785. eCollection 2017.

Pediatric acute kidney injury: prevalence, impact and management challenges

Eileen Ciccia  1 , Prasad Devarajan  1
Affiliations
Review

Pediatric acute kidney injury: prevalence, impact and management challenges

Eileen Ciccia et al. Int J Nephrol Renovasc Dis. .

Abstract

The incidence of pediatric acute kidney injury (AKI) is increasing globally, as are the associated morbidities and mortality. A recent standardization of the definition of AKI has allowed for a more accurate assessment of the epidemiology of pediatric AKI. Recent advances in leveraging electronic medical health record systems have allowed for real-time risk stratification and prevention of pediatric AKI in the hospital setting. Newly developed and validated clinical scores have improved our ability to predict AKI and provide a rational context for biomarker utilization in hospitalized children. Novel non-invasive diagnostic and predictive biomarkers have been launched globally to improve our ability to diagnose and predict AKI and its adverse outcomes as well as recovery. This review summarizes the most current literature, focusing on the epidemiology, management, and early diagnostic strategies in pediatric AKI.

Keywords: acute kidney injury; acute renal failure; biomarkers; children; epidemiology; neutrophil gelatinase-associated lipocalin.

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Conflict of interest statement

Disclosure PD is a co-inventor on patents (7776824 and 7977110) related to NGAL as a biomarker of kidney injury and declares licensing agreements with BioPorto Diagnostics and Abbott Diagnostics. EC reports no conflict of interest in this work.

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