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. 1979 Jan;76(1):425-9.
doi: 10.1073/pnas.76.1.425.

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex

B Chesebro, K Wehrly

Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex

B Chesebro et al. Proc Natl Acad Sci U S A. 1979 Jan.

Abstract

The dominant C57BL/10 allele of a single autosomal, non-H-2 gene (Rfv-3) was found to be required for recovery from viremia and leukemia induced by Friend virus complex in H-2b/b mice. In H-2a/a mice, the Rfv-3 gene apparently influenced recovery from viremia in the presence of persistent leukemia because these mice lacked the appropriate H-2 genotype for recovery from leukemia. The Rfv-3 gene was distinct from the Fv-2 gene because recovery from viremia was seen in recombinant-inbred mice with the Fv-2s/s genotype. Furthermore, backcross studies indicated that Rfv-3 and Fv-2 were not linked. The Rfv-3 gene may act by influencing the specific anti-FV humoral antibody response.

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References

    1. Jpn J Exp Med. 1962 Oct;32:405-13 - PubMed
    1. Cancer Res. 1959 Jan;19(1):52-8 - PubMed
    1. J Exp Med. 1957 Apr 1;105(4):307-18 - PubMed
    1. J Exp Med. 1977 Oct 1;146(4):1088-95 - PubMed
    1. J Exp Med. 1977 Oct 1;146(4):1079-87 - PubMed

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