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Review
. 2017 Jun;4(2):180-191.
doi: 10.1007/s40572-017-0134-3.

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

J L Allen  1 , C Klocke  1 , K Morris-Schaffer  1 , K Conrad  1 , M Sobolewski  1 , D A Cory-Slechta  2
Affiliations
Review

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

J L Allen et al. Curr Environ Health Rep. 2017 Jun.

Abstract

Purpose of review: This review sought to address the potential for air pollutants to impair cognition and mechanisms by which that might occur.

Recent findings: Air pollution has been associated with deficits in cognitive functions across a wide range of epidemiological studies, both with developmental and adult exposures. Studies in animal models are significantly more limited in number, with somewhat inconsistent findings to date for measures of learning, but show more consistent impairments for short-term memory. Potential contributory mechanisms include oxidative stress/inflammation, altered levels of dopamine and/or glutamate, and changes in synaptic plasticity/structure. Epidemiological studies are consistent with adverse effects of air pollutants on cognition, but additional studies and better phenotypic characterization are needed for animal models, including more precise delineation of specific components of cognition that are affected, as well as definitions of critical exposure periods for such effects and the components of air pollution responsible. This would permit development of more circumscribed hypotheses as to potential behavioral and neurobiological mechanisms.

Keywords: Air pollution; Attention; Glutamate; Inflammation; Learning; Memory.

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Conflict of interest statement

Conflict of Interest

J.L. Allen, C. Klocke, K. Morris-Schaffer, K. Conrad, M. Sobolewski, and D.A. Cory-Slechta declare that they have no conflict of interest.

References

    1. Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013 a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015:2287–323. doi: 10.1016/S0140-6736(15)00128-2. - DOI - PMC - PubMed
    1. Lelieveld J, Evans JS, Fnais M, Giannadaki D, Pozzer A. The contribution of outdoor air pollution sources to premature mortality on a global scale. Nature. 2015;525(7569):367–71. doi: 10.1038/nature15371. - DOI - PubMed
    1. Kumar P, Morawska L, Birmili W, Paasonen P, Hu M, Kulmala M, et al. Ultrafine particles in cities. Environ Int. 2014;66:1–10. doi: 10.1016/j.envint.2014.01.013. - DOI - PubMed
    1. Oberdorster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994;102(Suppl 5):173–9. - PMC - PubMed
    1. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol. 2001;175(3):191–9. doi: 10.1006/taap.2001.9240. - DOI - PubMed