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Meta-Analysis
. 2017 Jun;45(3):904-911.
doi: 10.1177/0300060517703276. Epub 2017 Apr 24.

Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: A meta-analysis

Min Zhu  1 , Chengmao Zhou  2 , Bing Huang  1 , Lin Ruan  1 , Rui Liang  1
Affiliations
Meta-Analysis

Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: A meta-analysis

Min Zhu et al. J Int Med Res. 2017 Jun.

Abstract

Objective This study was designed to compare the effectiveness of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods We searched the literature in the Cochrane Library, PubMed, EMBASE, and CNKI. Results In total, 11 randomized controlled trials were enrolled in this analysis. The meta-analysis showed that granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopy surgery. No significant differences in adverse reactions (dizziness and headache) were found in association with dexamethasone. Conclusion Granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopic surgery, with no difference in adverse reactions between the two groups. Granisetron alone or granisetron plus dexamethasone can be used to prevent PONV in patients undergoing laparoscopic surgery.

Keywords: Granisetron; dexamethasone; laparoscopic surgery; meta-analysis; postoperative nausea and vomiting.

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Figures

Figure 1.
Figure 1.
Flow diagram of the present meta-analysis.
Figure 2.
Figure 2.
Incidence of postoperative nausea and vomiting in the first 24 h after administering granisetron alone versus granisetron plus dexamethasone.
Figure 3.
Figure 3.
Incidence of adverse reactions (dizziness and headache) in the first 24 h after administering granisetron alone versus granisetron plus dexamethasone.
Figure 4.
Figure 4.
Incidence of postoperative nausea and vomiting in the first 24 h after administering granisetron plus dexamethasone versus saline.
Figure 5.
Figure 5.
Incidence of postoperative nausea and vomiting in the first 24 h after administering granisetron alone versus saline.
See this image and copyright information in PMC

References

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