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Case Reports
. 2017 Jul;32(7):1106-1108.
doi: 10.1002/mds.27020. Epub 2017 Apr 24.

Very late-onset pure autonomic failure

Alessandra Fanciulli  1 , Nadia Stefanova  1 , Christoph Scherfler  1 , Patrizia Moser  2 , Klaus Seppi  1 , Elke R Gizewski  3   4 , Irene Virgolini  5 , Sylvia Boesch  1 , Werner Poewe  1 , Gregor K Wenning  1
Affiliations
Case Reports

Very late-onset pure autonomic failure

Alessandra Fanciulli et al. Mov Disord. 2017 Jul.
No abstract available

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Conflict of interest statement

Conflict of interests: the authors declare no conflicts of interests

Figures

Figure 1
Figure 1
Panel A to C: double immunofluorescence for phosphorylated α-synuclein (pSyn - pSyn#64Wako, visualized with Alexa 594-conjugated anti-mouse IgG, Life Technologies), and neurofilament H (NF-H - NF-H Millipore, visualized with Alexa 488-conjugated anti-rabbit IgG, Life Technologies) demonstrates pSyn deposits in NF-positive fibres innervating sweat glands of abdominal skin biopsy. Susceptibility-weighted imaging on 3.0 tesla MR depicts an area of signal hyperintensity within the dorsolateral substantia nigra (arrows) corresponding to nigrosome 1 in a healthy subject (D). No visible signal increase in the dorsolateral substantia nigra of a patient with Parkinson’s disease (E), and our patient with PAF (F). 123I-Fluopane CIT in a healthy subject (G), in a patient with Parkinson’s disease (H), and in our patient with PAF (I). 123I-MIBG cardiac SPECT in a healthy subject (J) and in our patient, showing severe sympathetic post-ganglionic denervation (K).
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