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. 1979 Jan;76(1):499-503.
doi: 10.1073/pnas.76.1.499.

Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta

J G Hildebrand, L M Hall, B C Osmond

Distribution of binding sites for 125I-labeled alpha-bungarotoxin in normal and deafferented antennal lobes of Manduca sexta

J G Hildebrand et al. Proc Natl Acad Sci U S A. 1979 Jan.

Abstract

125I-Labeled alpha-bungarotoxin has been used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth Manduca sexta. Toxin-binding sites are confined to synaptic regions in deafferented lobes. These findings suggest that receptors can develop in the insect central nervous system independently of normal synaptic influences.

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