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Review
. 2017 Apr 24;11(1):118.
doi: 10.1186/s13256-017-1269-4.

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature

O Arouna  1 , F Deluca  2 , M Camara  3 , B Fall  4 , B Fall  5 , A Ba Diallo  3 , J D Docquier  2 , S Mboup  3
Affiliations
Review

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature

O Arouna et al. J Med Case Rep. .

Abstract

Background: Here we report a rare case of a urinary tract infection due to Chryseobacterium gleum. This widely distributed Gram-negative bacillus is an uncommon human pathogen and is typically associated with health care settings.

Case presentation: We describe a case of urinary tract infection caused by Chryseobacterium gleum in a 68-year-old man of Wolof ethnicity (an ethnic group in Senegal, West Africa) who presented to our Department of Urology in a university teaching hospital (Hôpital Aristide Le Dantec) in Dakar, Senegal, 1 month after prostatectomy. The strain isolated from a urine sample was identified as Chryseobacterium gleum by mass spectrometry (Vitek matrix-assisted laser desorption/ionization, time-of-flight, bioMérieux) and confirmed by 16S ribosomal ribonucleic acid sequencing. The organism was resistant to a wide range of antibiotics, including carbapenem, due to a resident metallo-β-lactamase gene that shared 99% of amino-acid identity with Chryseobacterium gleum class B enzym.

Conclusions: Infection by Chryseobacterium gleum is infrequent, and no such case has been previously reported in Africa. Despite its low virulence, Chryseobacterium gleum should be considered a potential opportunistic and emerging pathogen. Further studies on the epidemiology, pathogenicity, and resistance mechanisms of Chryseobacterium gleum are needed for better diagnosis and management.

Keywords: CGB-1; Chryseobacterium gleum case report; Metallo-β-lactamase; Urinary tract infection; resistance.

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Figures

Fig. 1
Fig. 1
Comparison of the amino acid sequence of β-lactamase CGB-1 with our strain. Broken lines indicate identical amino acid residues. The vertical arrow indicates the putative cleavage site for the leader peptide of CGB-1. Amino acids that may be involved in the binding of Zinc (Zn2+) or/and water are indicated with a star. Shading corresponds to the single amino-acid mutation occurring in the gene of our strain
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