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. 1988 May-Jun;9(3):575-81.
doi: 10.1016/0196-9781(88)90167-2.

Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats

F J Hock  1 , H J Gerhards, G Wiemer, P Usinger, R Geiger
Affiliations

Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats

F J Hock et al. Peptides. 1988 May-Jun.

Abstract

These experiments investigated the effects of the new ACTH4-9 analog ebiratide (Hoe 427) [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2 X 3 CH3COOH] on memory processes in mice and rats in five training tasks. With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.

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