doi: 10.1016/0196-9781(88)90167-2.
Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats
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- PMID: 2843833
- DOI: 10.1016/0196-9781(88)90167-2
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Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats
Peptides.
1988 May-Jun.
Abstract
These experiments investigated the effects of the new ACTH4-9 analog ebiratide (Hoe 427) [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2 X 3 CH3COOH] on memory processes in mice and rats in five training tasks. With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.
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