Review
doi: 10.1016/j.jhep.2017.04.009.
Epub 2017 Apr 22.
Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets
Affiliations
- PMID: 28438689
- DOI: 10.1016/j.jhep.2017.04.009
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Review
Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets
J Hepatol.
2017 Sep.
Abstract
The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer.
Keywords: Cancer stem cell; Epithelial–to-mesenchymal transition; HCC; Hepatocellular carcinoma; Liver cancer; Long non-coding RNA; STAT3; Wnt; lncRNA; microRNA.
Copyright © 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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