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Clinical Trial
. 2017 Apr 25;135(17):1671-1673.
doi: 10.1161/CIRCULATIONAHA.116.025338.

Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects

Weifei Zhu  1 , Zeneng Wang  1 , W H Wilson Tang  1 , Stanley L Hazen  2
Affiliations
Clinical Trial

Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects

Weifei Zhu et al. Circulation. .
No abstract available

Keywords: cardiovascular disease; diet; thrombus.

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Figures

Figure 1
Figure 1. Oral choline supplementation increases fasting TMAO levels, enhances platelet aggregation, and attenuates the anti-platelet effect observed with aspirin
A) Plasma TMAO levels and platelet aggregation in response to submaximal (5μM) ADP in vegan/vegetarian and omnivore groups. B) Correlation between plasma TMAO and platelet aggregation responses amongst the indicated groups. Spearman correlations and p values shown. C) Effect of choline supplementation on TMAO and platelet aggregation responses in omnivores in the absence versus presence of aspirin (ASA). All data shown are mean (±SEM) with the indicated number of subjects. Asterisks shown represent p<0.05 for comparison of aggregation responses off versus on ASA for the corresponding time point. P values were calculated with Wilcoxon Rank Sum test for two-group comparisons, and Wilcoxon Signed Rank Test for pairwise comparisons.
See this image and copyright information in PMC

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