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. 2017 May-Jun;31(3):365-371.
doi: 10.21873/invivo.11068.

Partial Deletions of Y-Chromosome in Infertile Men with Non-obstructive Azoospermia and Oligoasthenoteratozoospermia in a Turkish Population

Cemallettin Cengiz Beyaz  1 , Sezgin Gunes  2   3 , Kadir Onem  1 , Tuba Kulac  4 , Ramazan Asci  1   3
Affiliations

Partial Deletions of Y-Chromosome in Infertile Men with Non-obstructive Azoospermia and Oligoasthenoteratozoospermia in a Turkish Population

Cemallettin Cengiz Beyaz et al. In Vivo. 2017 May-Jun.

Abstract

Many genetic alterations have been identified to aid in understanding the genetic basis of male infertility, however, the cause of 30% of male infertility remains unknown. Some studies indicated that subdeletions of Y chromosome may be a reason for male infertility caused by testicular failure. In this regard, we aimed to investigate frequency of AZFc region subdeletions and their clinical effects in patients with idiopathic infertility. A total of 333 male infertile patients with non-obstructive azoospermia (NOA) or oligoasthenoteratozoospermia (OAT), and 87 normozoospermic controls were screened to detect gr/gr, b1/b3 and b2/b3 subdeletions. We recorded higher gr/gr deletion frequency in normozoospermic controls compared NAO and OAT groups (p=0.026). There were no significant differences in b2/b3 subdeletion rates among groups (p=0.437). In the OAT group, follicle-stimulating hormone levels of cases with b2/b3 deletion were statistically lower than cases without b2/b3 deletion (p=0.047). No statistical correlations were indicated among subdeletions, sperm count and assisted reproductive technology (ART) outcomes. These data demonstrate that gr/gr and b2/b3 subdeletions may not play a significant role in the etiopathogenesis of male infertility and ART outcomes in the studied population.

Keywords: Non-obstructive azoospermia; Y chromosome deletion; b1/b3; b2/b3; gr/gr; male infertility; oligoasthenoteratozoospermia.

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Figures

Figure 1
Figure 1. Y-Chromosome AZFc partial deletions
See this image and copyright information in PMC

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