Viral and viral protein specificity of antibodies induced in cows persistently infected with noncytopathic bovine viral diarrhea virus after vaccination with cytopathic bovine viral diarrhea virus
- PMID: 2844105
Viral and viral protein specificity of antibodies induced in cows persistently infected with noncytopathic bovine viral diarrhea virus after vaccination with cytopathic bovine viral diarrhea virus
Abstract
Neutralizing and nonneutralizing antibodies to bovine viral diarrhea (BVD) virus were detected in 3 cows persistently infected with noncytopathic BVD virus after vaccination with modified-live cytopathic BVD virus. Neutralizing antibodies detected in serum samples from each persistently infected cow at 3 weeks after vaccination were highly specific for certain isolates of cytopathic BVD virus and reacted only with a viral protein with a molecular weight of 53,000. Neutralizing antibodies to 1 of 3 isolates of noncytopathic BVD virus were detected in a serum sample obtained at 12 weeks after vaccination from 1 of 3 persistently infected cows. Nonneutralizing antibodies were detected in all cows at 7 to 12 weeks after vaccination. The nonneutralizing antibodies were less specific for isolates of BVD virus and reacted with viral proteins with molecular weights of 115,000, 80,000, 53,000, and 47,000.
Similar articles
-
Response of cattle persistently infected with noncytopathic bovine viral diarrhea virus to vaccination for bovine viral diarrhea and to subsequent challenge exposure with cytopathic bovine viral diarrhea virus.Am J Vet Res. 1985 Dec;46(12):2467-70. Am J Vet Res. 1985. PMID: 3002214
-
Specificity of neutralizing and precipitating antibodies induced in healthy calves by monovalent modified-live bovine viral diarrhea virus vaccines.Am J Vet Res. 1989 Jun;50(6):817-21. Am J Vet Res. 1989. PMID: 2548419
-
Range of viral neutralizing activity and molecular specificity of antibodies induced in cattle by inactivated bovine viral diarrhea virus vaccines.Am J Vet Res. 1990 May;51(5):703-7. Am J Vet Res. 1990. PMID: 2159737
-
[How the bovine viral diarrhea virus outwits the immune system].Dtsch Tierarztl Wochenschr. 2006 Apr;113(4):124-9. Dtsch Tierarztl Wochenschr. 2006. PMID: 16716045 Review. German.
-
[Bovine virus diarrhea/mucosal disease virus: diagnosis and approach in clinical practice].Tijdschr Diergeneeskd. 1989 Sep 1;114(17):877-85. Tijdschr Diergeneeskd. 1989. PMID: 2678589 Review. Dutch.
Cited by
-
Characterization of structural and non-structural proteins of hog cholera virus by means of monoclonal antibodies.Arch Virol. 1993;131(3-4):405-17. doi: 10.1007/BF01378641. Arch Virol. 1993. PMID: 7688508
-
Bovine viral diarrhea virus: biotypes and disease.Can Vet J. 1995 Jun;36(6):371-8. Can Vet J. 1995. PMID: 7648541 Free PMC article. Review.
-
Ruminant pestiviruses.Br Vet J. 1995 Nov-Dec;151(6):615-42. doi: 10.1016/s0007-1935(95)80145-6. Br Vet J. 1995. PMID: 8605577 Free PMC article. Review.
-
Molecular biology of bovine viral diarrhea virus and its interactions with the host.Vet Clin North Am Food Anim Pract. 1995 Nov;11(3):393-423. doi: 10.1016/s0749-0720(15)30459-x. Vet Clin North Am Food Anim Pract. 1995. PMID: 8581855 Free PMC article. Review.
-
Viral protein production in homogeneous and mixed infections of cytopathic and noncytopathic BVD virus.Arch Virol. 1990;111(3-4):247-56. doi: 10.1007/BF01311058. Arch Virol. 1990. PMID: 2162163