Gut Microbiota: Small Molecules Modulate Host Cellular Functions

Jacob M Luber¹, Aleksandar D Kostic²

Affiliations

¹ Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jluber@g.harvard.edu.
² Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aleksandar.kostic@joslin.harvard.edu.

PMID: 28441565
DOI: 10.1016/j.cub.2017.03.026

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Gut Microbiota: Small Molecules Modulate Host Cellular Functions

Jacob M Luber et al. Curr Biol. 2017.

Free article

. 2017 Apr 24;27(8):R307-R310.

doi: 10.1016/j.cub.2017.03.026.

Authors

Jacob M Luber¹, Aleksandar D Kostic²

Affiliations

¹ Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jluber@g.harvard.edu.
² Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA 02215, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aleksandar.kostic@joslin.harvard.edu.

PMID: 28441565
DOI: 10.1016/j.cub.2017.03.026

Abstract

The human gut metagenome was recently discovered to encode vast collections of biosynthetic gene clusters with diverse chemical potential, almost none of which are yet functionally validated. Recent work elucidates common microbiome-derived biosynthetic gene clusters encoding peptide aldehydes that inhibit human proteases.

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Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Guo CJ, et al. Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19. Cell. 2017. PMID: 28111075 Free PMC article.

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Gut Microbiota: Small Molecules Modulate Host Cellular Functions

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Gut Microbiota: Small Molecules Modulate Host Cellular Functions

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