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. 1979 Feb;76(2):912-4.
doi: 10.1073/pnas.76.2.912.

IgM receptors on human lymphocytes: detection by direct binding

J A Hardin, K K Nakaoka, J M Carboni

IgM receptors on human lymphocytes: detection by direct binding

J A Hardin et al. Proc Natl Acad Sci U S A. 1979 Feb.

Abstract

Radioiodinated IgM isolated from a patient with Waldenström macroglobulinemia binds with high avidity (apparent Ka = 2.5 x 10(9) M-1) to freshly isolated human peripheral blood lymphocytes. Binding occurred through the Fc region of the molecule and involved a receptor specific for immunoglobulins of the IgM class. The avidity and specificity of this binding are consistent with a biologic role for IgM receptors on lymphocytes.

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References

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