Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr 22;18(4):889.
doi: 10.3390/ijms18040889.

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Stella Cosenza  1 , Maxime Ruiz  2 , Marie Maumus  3 , Christian Jorgensen  4   5 , Danièle Noël  6   7
Affiliations
Review

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

Stella Cosenza et al. Int J Mol Sci. .

Abstract

Extracellular vesicles (EVs) are important mediators of cell-to-cell communication pathways via the transport of proteins, mRNA, miRNA and lipids. There are three main types of EVs, exosomes, microparticles and apoptotic bodies, which are classified according to their size and biogenesis. EVs are secreted by all cell types and their function reproduces that of the parental cell. They are involved in many biological processes that regulate tissue homeostasis and physiopathology of diseases. In rheumatic diseases, namely osteoarthritis (OA) and rheumatoid arthritis (RA), EVs have been isolated from synovial fluid and shown to play pathogenic roles contributing to progression of both diseases. By contrast, EVs may have therapeutic effect via the delivery of molecules that may stop disease evolution. In particular, EVs derived from mesenchymal stem cells (MSCs) reproduce the main functions of the parental cells and therefore represent the ideal type of EVs for modulating the course of either disease. The aim of this review is to discuss the role of EVs in OA and RA focusing on their potential pathogenic effect and possible therapeutic options. Special attention is given to MSCs and MSC-derived EVs for modulating OA and RA progression with the perspective of developing innovative therapeutic strategies.

Keywords: cell therapy; exosome; extracellular vesicle; mesenchymal stem cell; microparticle; osteoarthritis; rheumatoid arthritis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Colombo M., Raposo G., Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 2014;30:255–289. doi: 10.1146/annurev-cellbio-101512-122326. - DOI - PubMed
    1. Gao T., Guo W., Chen M., Huang J., Yuan Z., Zhang Y., Wang M., Li P., Peng J., Wang A., et al. Extracellular Vesicles and Autophagy in Osteoarthritis. Biomed. Res. Int. 2016;2016:2428915. doi: 10.1155/2016/2428915. - DOI - PMC - PubMed
    1. Ali S.Y., Griffiths S. Formation of calcium phosphate crystals in normal and osteoarthritic cartilage. Ann. Rheum. Dis. 1983;42(Suppl. 1):45–48. doi: 10.1136/ard.42.Suppl_1.45. - DOI - PMC - PubMed
    1. Withrow J., Murphy C., Liu Y., Hunter M., Fulzele S., Hamrick M.W. Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis. Arthritis Res. Ther. 2016;18:286. doi: 10.1186/s13075-016-1178-8. - DOI - PMC - PubMed
    1. Kato T., Miyaki S., Ishitobi H., Nakamura Y., Nakasa T., Lotz M.K., Ochi M. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res. Ther. 2014;16:R163. doi: 10.1186/ar4679. - DOI - PMC - PubMed

MeSH terms