Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr 20;20(4):259-263.
doi: 10.3779/j.issn.1009-3419.2017.04.06.

[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer]

[Article in Chinese]
Xiaohui Liang  1 , Baocun Sun  1 , Jiyuan Han  1 , Xiulan Zhao  1 , Zenghui Liu  1
Affiliations

[Expression and Clinical Significance of Progesterone and Adiponectin Receptor Family Member 3 in Lung Cancer]

[Article in Chinese]
Xiaohui Liang et al. Zhongguo Fei Ai Za Zhi. .

Abstract
in English, Chinese

Background: Progesterone and adiponectin receptor family member 3 (PAQR3) is a recently discovered tumor suppressor gene, which affects the development of a tumor by inhibiting cell proliferation, cell malignant transformation, angiogenesis, and tumor metastasis. This study investigates the expression of PAQR3 in lung cancer and its clinical significance.

Methods: A total of 106 patients with lung cancer received surgical treatment in hospital, and adjacent normal tissues of these patients were utilized as control group. The diagnosis of all patients was confirmed through clinical pathology. The expression of PAQR3 protein was detected by immunohistochemistry in lung cancer and adjacent normal tissues. The clinical significance of its expression was also investigated.

Results: The positive expression rate of PAQR3 protein in lung cancer was lower than that in adjacent normal tissues (P<0.01). The positive expression rate of PAQR3 protein was unrelated to age, tumor size, and gender, but it exhibited a significant relationship with the pathological type and differentiation, TNM staging, and lymph node metastasis (P<0.05). Kaplan-Meier survival analysis showed that the five-year survival rate of patients with PAQR3 protein positive expression was higher than that in patients with negative expression (P=0.026).

Conclusions: The expression of PAQR3 protein significantly decreased in lung cancer, indicating that PAQR3 protein plays an important role in the pathogenesis of PAQR3 in lung cancer.

背景与目的 孕酮及脂联素受体家族成员3（progesterone and adiponectin receptor family member 3, PAQR3）是最新研究发现的抑癌基因，通过抑制细胞增殖、细胞恶性转化、抑制血管生成及肿瘤转移来影响肿瘤的发展。本研究旨在探讨PAQR3在肺癌组织中的表达及其临床意义。方法 选取天津医科大学总医院病理科2008年1月-2010年12月经病理明确诊断的106例肺癌组织标本作为实验组，同时取其癌旁正常组织作为对照。所有患者的诊断均经术后病理诊断证实，采用免疫组织化学方法检测PAQR3蛋白在肺癌组织和癌旁正常组织中的表达，并探讨其表达的临床意义。结果 PAQR3蛋白在肺癌组织中阳性表达率显著低于癌旁正常组织（P<0.01）；PAQR3蛋白的阳性表达率与患者的性别、年龄、肿瘤大小无关，与患者的病理分型、分化程度、TNM分期和有无淋巴结转移具有相关性（P<0.05）；Kaplan-Meier生存分析结果显示PAQR3蛋白阳性表达的患者5年生存率高于阴性表达的患者（P<0.05）。结论 PAQR3蛋白的表达量在肺癌组织中明显降低，提示PAQR3可能在肺癌的发病机制中发挥重要的作用。.

PubMed Disclaimer

Figures

1
1
肺癌和癌旁正常肺组织中PAQR3的表达（免疫组化染色，A、B：200×，C、D：100×）。A、C：肺癌组织中PAQR3的阴性表达；B、D：正常肺组织中PAQR3的阳性表达（箭头所示） The expression of PAQR3 in lung cancer and adjacent normal tissues (IHC, A, B: 200×; C, D: 100×). A, C: Negative expression of PAQR3 in lung cancer tissue; B, D: Positive expression of PAQR3 in adjacent normal tissues
2
2
PAQR3表达量与肺癌患者5年生存率之间的关系 Kaplan-Meier survival curve of the expression of PAQR3 in 106 patients with lung cancer
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China. CA Cancer J Clin. 2016;66(2):115–132. doi: 10.3322/caac.21338. - DOI - PubMed
    1. Zheng R, Zeng H, Zhang S, et al. National estimates of cancer prevalence in China, 2011. Cancer Lett. 2016;370(1):33–38. doi: 10.1016/j.canlet.2015.10.003. - DOI - PubMed
    1. Jones JM, Olson K, Catton P, et al. Cancer-related fatigue and associated disability in post treatment cancer survivors. J Cancer Surviv. 2016;10(1):51–61. doi: 10.1007/s11764-015-0450-2. - DOI - PubMed
    1. Feng L, Xie X, Ding Q, et al. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A. 2007;104(36):14348–14353. doi: 10.1073/pnas.0701298104. - DOI - PMC - PubMed
    1. Ma Z, Wang Y, Piao T, et al. The tumor suppresser role of PAQR3 in osteosarcoma. https://link.springer.com/article/10.1007/s13277-014-2964-z Tumour Biol. 2016;36(5):3319–3324. - PubMed