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Comment
. 2017 May 2;114(18):4576-4578.
doi: 10.1073/pnas.1704103114. Epub 2017 Apr 25.

Mind the magnesium, in dantrolene suppression of malignant hyperthermia

Stephen C Cannon  1
Affiliations
Comment

Mind the magnesium, in dantrolene suppression of malignant hyperthermia

Stephen C Cannon. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

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References

    1. Loke J, MacLennan DH. Malignant hyperthermia and central core disease: Disorders of Ca2+ release channels. Am J Med. 1998;104:470–486. - PubMed
    1. Kolb ME, Horne ML, Martz R. Dantrolene in human malignant hyperthermia. Anesthesiology. 1982;56:254–262. - PubMed
    1. Szentesi P, et al. Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers. J Gen Physiol. 2001;118:355–375. - PMC - PubMed
    1. Fruen BR, Mickelson JR, Louis CF. Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors. J Biol Chem. 1997;272:26965–26971. - PubMed
    1. Choi RH, Koenig X, Launikonis BS. Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proc Natl Acad Sci USA. 2017;114:4811–4815. - PMC - PubMed

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